Control of chronic Strongyloides stercoralis infection in an endemic community may be possible by pharmacological means alone: Results of a three-year cohort study

To assess the effect of treatment with ivermectin on the prevalence of S. stercoralis infection in an Australian Aboriginal population over a three year period, and to assess the validity of using a lower ELISA cut-off in diagnosis. A three-year cohort study of 259 adult Australian Aboriginals livin...

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Bibliographic Details
Published in:PLoS neglected tropical diseases 2017-07, Vol.11 (7), p.e0005825
Main Authors: Hays, Russell, Esterman, Adrian, McDermott, Robyn
Format: Article
Language:English
Subjects:
Adult
Aged
Analysis
Animals
Australia - epidemiology
Biology and Life Sciences
Chronic Disease
Chronic illnesses
Chronic infection
Cohort analysis
Cohorts
Communities
Diabetes
Disease prevention
Drug therapy
ELISA
Enzyme-Linked Immunosorbent Assay
Feces - parasitology
Female
Follow-Up Studies
Health aspects
Helminthiasis
Humans
Indigenous peoples
Infections
Ivermectin
Ivermectin - administration & dosage
Logistic Models
Male
Medicine and Health Sciences
Middle Aged
Native peoples
Parasitic diseases
People and Places
Pharmacology
Prevalence studies (Epidemiology)
Prevention
Public health
Risk factors
Serology
Strongyloides stercoralis - isolation & purification
Strongyloidiasis - diagnosis
Strongyloidiasis - drug therapy
Testing
Treatment Outcome
Tropical diseases
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Summary:To assess the effect of treatment with ivermectin on the prevalence of S. stercoralis infection in an Australian Aboriginal population over a three year period, and to assess the validity of using a lower ELISA cut-off in diagnosis. A three-year cohort study of 259 adult Australian Aboriginals living in a remote community in northern Australia. S stercoralis infection was diagnosed using commercial ELISA testing, and employed a lower threshold for treatment than that recommended. Follow up was conducted at 6 months and 3 years following ivermectin treatment. Treatment with ivermectin was highly effective and resulted in a sustained fall in the prevalence of infection in the study group (Initial prevalence 35.3%, 3 year prevalence 5.8%, McNemar's chi2 = 56.5, p
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0005825