Association between mitochondrial DNA variations and schizophrenia in the northern Chinese Han population

To determine whether mitochondrial DNA (mtDNA) variations are associated with schizophrenia, 313 patients with schizophrenia and 326 unaffected participants of the northern Chinese Han population were included in a prospective study. Single-nucleotide polymorphisms (SNPs) including C5178A, A10398G,...

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Bibliographic Details
Published in:PloS one 2017-08, Vol.12 (8), p.e0182769-e0182769
Main Authors: Xu, Feng-Ling, Ding, Mei, Yao, Jun, Shi, Zhang-Sen, Wu, Xue, Zhang, Jing-Jing, Pang, Hao, Xing, Jia-Xin, Xuan, Jin-Feng, Wang, Bao-Jie
Format: Article
Language:English
Subjects:
Adult
Asian Continental Ancestry Group - genetics
Biology and Life Sciences
Bipolar disorder
China
Deoxyribonucleic acid
DNA
DNA, Mitochondrial - genetics
Female
Forensic medicine
Genetic Association Studies
Genetic Predisposition to Disease
Haplotypes
Humans
Male
Medicine and Health Sciences
Mental disorders
Middle Aged
Mitochondrial DNA
Mutation
People and places
Polymerase chain reaction
Polymorphism
Polymorphism, Single Nucleotide
Research and Analysis Methods
Restriction fragment length polymorphism
Schizophrenia
Schizophrenia - genetics
Single-nucleotide polymorphism
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Summary:To determine whether mitochondrial DNA (mtDNA) variations are associated with schizophrenia, 313 patients with schizophrenia and 326 unaffected participants of the northern Chinese Han population were included in a prospective study. Single-nucleotide polymorphisms (SNPs) including C5178A, A10398G, G13708A, and C13928G were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Hypervariable regions I and II (HVSI and HVSII) were analyzed by sequencing. The results showed that the 4 SNPs and 11 haplotypes, composed of the 4 SNPs, did not differ significantly between patient and control groups. No significant association between haplogroups and the risk of schizophrenia was ascertained after Bonferroni correction. Drawing a conclusion, there was no evidence of an association between mtDNA (the 4 SNPs and the control region) and schizophrenia in the northern Chinese Han population.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0182769