Acylcarnitines profile best predicts survival in horses with atypical myopathy

Equine atypical myopathy (AM) is caused by hypoglycin A intoxication and is characterized by a high fatality rate. Predictive estimation of survival in AM horses is necessary to prevent unnecessary suffering of animals that are unlikely to survive and to focus supportive therapy on horses with a pos...

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Bibliographic Details
Published in:PloS one 2017-08, Vol.12 (8), p.e0182761-e0182761
Main Authors: Boemer, François, Detilleux, Johann, Cello, Christophe, Amory, Hélène, Marcillaud-Pitel, Christel, Richard, Eric, van Galen, Gaby, van Loon, Gunther, Lefère, Laurence, Votion, Dominique-Marie
Format: Article
Language:English
Subjects:
Acer
Acer pseudoplatanus
Acylcarnitines
Animal biology
Animal diseases
Animals
Atypical myopathy
Biology and Life Sciences
Carnitine - analogs & derivatives
Carnitine - blood
Cheval
Dehydrogenases
Erables
Fatty acids
Health risks
Horse
Horse Diseases - blood
Horse Diseases - mortality
Horses
Internal medicine
Intoxication
Laboratories
Life Sciences
Maple tree
Mathematical models
Medical prognosis
Medicine and Health Sciences
Multivariate analysis
Muscular Diseases - blood
Muscular Diseases - mortality
Muscular Diseases - veterinary
Myopathie
Myopathie atypique
Myopathy
Médecine vétérinaire & santé animale
Oxidation
Prognosis
Rhabdomyolysis
Sciences du vivant
Statistical models
Studies
Survival
Survival Rate
Urine
Veterinary medicine
Veterinary medicine & animal health
Veterinary medicine and animal Health
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Summary:Equine atypical myopathy (AM) is caused by hypoglycin A intoxication and is characterized by a high fatality rate. Predictive estimation of survival in AM horses is necessary to prevent unnecessary suffering of animals that are unlikely to survive and to focus supportive therapy on horses with a possible favourable prognosis of survival. We hypothesized that outcome may be predicted early in the course of disease based on the assumption that the acylcarnitine profile reflects the derangement of muscle energetics. We developed a statistical model to prognosticate the risk of death of diseased animals and found that estimation of outcome may be drawn from three acylcarnitines (C2, C10:2 and C18 -carnitines) with a high sensitivity and specificity. The calculation of the prognosis of survival makes it possible to distinguish the horses that will survive from those that will die despite severe signs of acute rhabdomyolysis in both groups.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0182761