Alteration of Endothelin 1, MCP-1 and Chromogranin A in patients with atrial fibrillation undergoing pulmonary vein isolation

The relation between arrhythmias and stress is known. The aim of our current study was to elucidate whether plasma levels of previously described stress parameters are altered in highly symptomatic patients with atrial fibrillation (AF) per se and in patients undergoing ablation therapy by pulmonary...

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Bibliographic Details
Published in:PloS one 2017-09, Vol.12 (9), p.e0184337-e0184337
Main Authors: Lackermair, K, Clauss, S, Voigt, T, Klier, I, Summo, C, Hildebrand, B, Nickel, T, Estner, H L, Kääb, S, Wakili, R, Wilbert-Lampen, U
Format: Article
Language:English
Subjects:
Ablation
Aged
Atrial Fibrillation - blood
Atrial Fibrillation - physiopathology
Authorship
Bioindicators
Biology and Life Sciences
Biomarkers
Cardiac arrhythmia
Catheters
Chemokine CCL2 - blood
Chromogranin A - blood
Endothelin 1
Endothelin-1 - blood
Ethics
Family medical history
Fibrillation
Heart
Humans
Medicine
Medicine and Health Sciences
Middle Aged
Monocyte chemoattractant protein 1
Patients
Plasma levels
Pulmonary Veins
Restoration
Rhythm
Sinus
Social Sciences
Stress
Stress, Physiological
Stresses
Therapy
Veins & arteries
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Summary:The relation between arrhythmias and stress is known. The aim of our current study was to elucidate whether plasma levels of previously described stress parameters are altered in highly symptomatic patients with atrial fibrillation (AF) per se and in patients undergoing ablation therapy by pulmonary vein isolation (PVI). 96 patients with AF undergoing PVI were recruited. Plasma levels of Endothelin-1 (ET-1), MCP-1 and Chromogranin-A (CGA) were measured before and three months after ablation completed with clinical follow-up with respect to AF recurrence. Additionally, we examined 40 healthy age- and sex-matched volunteers as a reference. Symptomatic AF patients showed increased levels of ET-1 compared to healthy controls (2.62pg/ml vs. 1.57pg/ml; p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0184337