Lifestyle factors and oncogenic papillomavirus infection in a high-risk male population

• Published in: PloS one 2017-09, Vol.12 (9), p.e0184492-e0184492
• Main Authors: Lopez-Diez, Elena, Perez, Sonia, Carballo, Manuel, Iñarrea, Amparo, de la Orden, Angel, Castro, Maximo, Rodríguez, Moises, Almuster, Sheila, Montero, Ruben, Perez, Miguel, Sanchez, Jorge, Ojea, Antonio
• Format: Article
• Language: English
• Subjects: Adult; Aged; Biology and life sciences; Cervical cancer; Circumcision; Condyloma acuminatum; Condylomata Acuminata - epidemiology; Condylomata Acuminata - virology; Disease transmission; Epidemiology; Female; Genotyping; Habits; Health aspects; Health risk assessment; Health risks; Human papillomavirus; Humans; Infections; Inspection; Lesions; Life Style; Lifestyles; Male; Males; Medicine and Health Sciences; Men; Middle Aged; Multivariate analysis; Papillomaviridae - genetics; Papillomaviridae - isolation & purification; Papillomavirus infections; Population (statistical); Prevalence studies (Epidemiology); Prevention; Quality; Risk analysis; Risk factors; Sexual Behavior; Sexual Partners; Smoking; Squamous Intraepithelial Lesions of the Cervix - epidemiology; Squamous Intraepithelial Lesions of the Cervix - virology; Statistical analysis; Statistical methods; Statistics; Warts
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0184492

High risk human papillomavirus (HR-HPV) infection in males is a health issue with implications for HPV-related lesions in their partners. The identification of risk factors for male infection may improve our understanding of HR-HPV transmission and prevention. The aim of this study was to evaluate the relationships between lifestyle, genital warts and HR-HPV infection. The study was focused on men with an increased risk of HR-HPV infection: male sexual partners of women diagnosed with high-grade squamous intraepithelial cervical lesions. Men were enrolled and prospectively recruited within the first six months after diagnosis of cervical lesions in their female partners (n = 175, 2013-2016). Epidemiological and sexual behaviour data were obtained. The presence of genital warts was established by visual inspection. Detection and genotyping of HR-HPV infection in genital samples were performed with a Linear Array HPV Genotyping Test. All HR-HPV positive men were offered a follow-up exam at 12 months. SPSS version 19 was used for statistical analysis. The prevalence of HR-HPV infection in men was 45.1% (79/175). Genital warts were observed in 10.3% (18/175) of the subjects. Detection of genital warts (OR 3.5, p = 0.015), smoking habits (OR 2.3, p = 0.006) and sexual debut before 16 years old (OR 2, p = 0.035) were associated with an increased risk for HR-HPV infection (univariate analysis). This association was also observed for genital warts and smoking status in a multivariate analysis. The same genotype was found after one year in 71.4% (20/28) of subjects. The presence of genital warts and smoking habits seem to be associated with a higher risk of HR-HPV infection in males. Earlier sexual debut may increase this risk. Extensive knowledge of the natural history of HR-HPV infection in males is an absolute requirement for the design and implementation of prevention strategies for the general population as well as for specific populations such as couples after treatment for high-grade cervical lesions.