Correlation of serum cartilage oligometric matrix protein (COMP) and interleukin-16 (IL-16) levels with disease severity in primary knee osteoarthritis: A pilot study in a Malaysian population

Objective The aim of this study was to investigate the correlations between serum cartilage oligomeric matrix protein (COMP), interleukin-16 (IL-16) and different grades of knee osteoarthritis (KOA) in Malaysian subjects. Methods Ninety subjects were recruited comprising 30 with Kellgren-Lawrence (K...

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Bibliographic Details
Published in:PloS one 2017-09, Vol.12 (9), p.e0184802
Main Authors: Das Gupta, Esha, Ng, Wei Ren, Wong, Shew Fung, Bhurhanudeen, Abdul Kareem, Yeap, Swan Sim
Format: Article
Language:English
Subjects:
Arthritis
Biocompatibility
Biology and Life Sciences
Biomarkers
Breakdowns
Cartilage
Cartilage diseases
Cartilage oligomeric matrix protein
Correlation
Correlation analysis
Cytokines
Disease prevention
Enzyme-linked immunosorbent assay
Inflammation
Interleukin
Interleukin 16
Internal medicine
Knee
Matrix protein
Medicine
Medicine and Health Sciences
Minority & ethnic groups
Normal distribution
Osteoarthritis
Pain
Patients
Physical Sciences
Population
Population studies
Proteins
Quality
Rheumatology
Stiffness
Studies
X rays
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Summary:Objective The aim of this study was to investigate the correlations between serum cartilage oligomeric matrix protein (COMP), interleukin-16 (IL-16) and different grades of knee osteoarthritis (KOA) in Malaysian subjects. Methods Ninety subjects were recruited comprising 30 with Kellgren-Lawrence (K-L) grade 2 KOA, 27 with K-L grade 3 KOA, 7 with grade 4 KOA, and 30 healthy controls. All subjects completed the Western Ontario and McMaster Universities Arthritis Index (WOMAC) questionnaire. Serum COMP and IL-16 levels were measured using ELISA and their values log transformed to ensure a normal distribution. Results There was no significant differences in levels of log serum COMP and IL-16 between healthy controls and KOA patients. There were no significant differences in the log serum COMP and IL-16 levels within the different K-L grades in the KOA patients. In KOA patients, log serum IL-16 levels significantly correlated with the WOMAC score (p = 0.001) and its subscales, pain (p = 0.005), stiffness (p = 0.019) and physical function (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0184802