Correlation of serum cartilage oligometric matrix protein (COMP) and interleukin-16 (IL-16) levels with disease severity in primary knee osteoarthritis: A pilot study in a Malaysian population

Objective The aim of this study was to investigate the correlations between serum cartilage oligomeric matrix protein (COMP), interleukin-16 (IL-16) and different grades of knee osteoarthritis (KOA) in Malaysian subjects. Methods Ninety subjects were recruited comprising 30 with Kellgren-Lawrence (K...

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Published in:PloS one 2017-09, Vol.12 (9), p.e0184802
Main Authors: Das Gupta, Esha, Ng, Wei Ren, Wong, Shew Fung, Bhurhanudeen, Abdul Kareem, Yeap, Swan Sim
Format: Article
Language:English
Subjects:
Arthritis
Biocompatibility
Biology and Life Sciences
Biomarkers
Breakdowns
Cartilage
Cartilage diseases
Cartilage oligomeric matrix protein
Correlation
Correlation analysis
Cytokines
Disease prevention
Enzyme-linked immunosorbent assay
Inflammation
Interleukin
Interleukin 16
Internal medicine
Knee
Matrix protein
Medicine
Medicine and Health Sciences
Minority & ethnic groups
Normal distribution
Osteoarthritis
Pain
Patients
Physical Sciences
Population
Population studies
Proteins
Quality
Rheumatology
Stiffness
Studies
X rays
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description Objective The aim of this study was to investigate the correlations between serum cartilage oligomeric matrix protein (COMP), interleukin-16 (IL-16) and different grades of knee osteoarthritis (KOA) in Malaysian subjects. Methods Ninety subjects were recruited comprising 30 with Kellgren-Lawrence (K-L) grade 2 KOA, 27 with K-L grade 3 KOA, 7 with grade 4 KOA, and 30 healthy controls. All subjects completed the Western Ontario and McMaster Universities Arthritis Index (WOMAC) questionnaire. Serum COMP and IL-16 levels were measured using ELISA and their values log transformed to ensure a normal distribution. Results There was no significant differences in levels of log serum COMP and IL-16 between healthy controls and KOA patients. There were no significant differences in the log serum COMP and IL-16 levels within the different K-L grades in the KOA patients. In KOA patients, log serum IL-16 levels significantly correlated with the WOMAC score (p = 0.001) and its subscales, pain (p = 0.005), stiffness (p = 0.019) and physical function (p
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Methods Ninety subjects were recruited comprising 30 with Kellgren-Lawrence (K-L) grade 2 KOA, 27 with K-L grade 3 KOA, 7 with grade 4 KOA, and 30 healthy controls. All subjects completed the Western Ontario and McMaster Universities Arthritis Index (WOMAC) questionnaire. Serum COMP and IL-16 levels were measured using ELISA and their values log transformed to ensure a normal distribution. Results There was no significant differences in levels of log serum COMP and IL-16 between healthy controls and KOA patients. There were no significant differences in the log serum COMP and IL-16 levels within the different K-L grades in the KOA patients. In KOA patients, log serum IL-16 levels significantly correlated with the WOMAC score (p = 0.001) and its subscales, pain (p = 0.005), stiffness (p = 0.019) and physical function (p&lt;0.0001). Serum IL-16 levels were significantly higher in Malaysian Indians compared to Malays and Chinese (p = 0.024). Conclusions In this multi-ethnic Malaysian population, there was no difference in serum COMP and IL-16 levels between healthy controls and patients with KOA, nor was there any difference in serum COMP or IL-16 levels across the various K-L grades of KOA. However, there were significant inter-racial differences in serum IL-16 levels.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0184802</identifier><identifier>PMID: 28910372</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Arthritis ; Biocompatibility ; Biology and Life Sciences ; Biomarkers ; Breakdowns ; Cartilage ; Cartilage diseases ; Cartilage oligomeric matrix protein ; Correlation ; Correlation analysis ; Cytokines ; Disease prevention ; Enzyme-linked immunosorbent assay ; Inflammation ; Interleukin ; Interleukin 16 ; Internal medicine ; Knee ; Matrix protein ; Medicine ; Medicine and Health Sciences ; Minority &amp; ethnic groups ; Normal distribution ; Osteoarthritis ; Pain ; Patients ; Physical Sciences ; Population ; Population studies ; Proteins ; Quality ; Rheumatology ; Stiffness ; Studies ; X rays</subject><ispartof>PloS one, 2017-09, Vol.12 (9), p.e0184802</ispartof><rights>2017 Das Gupta et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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Methods Ninety subjects were recruited comprising 30 with Kellgren-Lawrence (K-L) grade 2 KOA, 27 with K-L grade 3 KOA, 7 with grade 4 KOA, and 30 healthy controls. All subjects completed the Western Ontario and McMaster Universities Arthritis Index (WOMAC) questionnaire. Serum COMP and IL-16 levels were measured using ELISA and their values log transformed to ensure a normal distribution. Results There was no significant differences in levels of log serum COMP and IL-16 between healthy controls and KOA patients. There were no significant differences in the log serum COMP and IL-16 levels within the different K-L grades in the KOA patients. In KOA patients, log serum IL-16 levels significantly correlated with the WOMAC score (p = 0.001) and its subscales, pain (p = 0.005), stiffness (p = 0.019) and physical function (p&lt;0.0001). Serum IL-16 levels were significantly higher in Malaysian Indians compared to Malays and Chinese (p = 0.024). Conclusions In this multi-ethnic Malaysian population, there was no difference in serum COMP and IL-16 levels between healthy controls and patients with KOA, nor was there any difference in serum COMP or IL-16 levels across the various K-L grades of KOA. 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Methods Ninety subjects were recruited comprising 30 with Kellgren-Lawrence (K-L) grade 2 KOA, 27 with K-L grade 3 KOA, 7 with grade 4 KOA, and 30 healthy controls. All subjects completed the Western Ontario and McMaster Universities Arthritis Index (WOMAC) questionnaire. Serum COMP and IL-16 levels were measured using ELISA and their values log transformed to ensure a normal distribution. Results There was no significant differences in levels of log serum COMP and IL-16 between healthy controls and KOA patients. There were no significant differences in the log serum COMP and IL-16 levels within the different K-L grades in the KOA patients. In KOA patients, log serum IL-16 levels significantly correlated with the WOMAC score (p = 0.001) and its subscales, pain (p = 0.005), stiffness (p = 0.019) and physical function (p&lt;0.0001). Serum IL-16 levels were significantly higher in Malaysian Indians compared to Malays and Chinese (p = 0.024). Conclusions In this multi-ethnic Malaysian population, there was no difference in serum COMP and IL-16 levels between healthy controls and patients with KOA, nor was there any difference in serum COMP or IL-16 levels across the various K-L grades of KOA. However, there were significant inter-racial differences in serum IL-16 levels.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>28910372</pmid><doi>10.1371/journal.pone.0184802</doi><orcidid>https://orcid.org/0000-0002-0474-3667</orcidid><oa>free_for_read</oa></addata></record>
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subjects Arthritis
Biocompatibility
Biology and Life Sciences
Biomarkers
Breakdowns
Cartilage
Cartilage diseases
Cartilage oligomeric matrix protein
Correlation
Correlation analysis
Cytokines
Disease prevention
Enzyme-linked immunosorbent assay
Inflammation
Interleukin
Interleukin 16
Internal medicine
Knee
Matrix protein
Medicine
Medicine and Health Sciences
Minority & ethnic groups
Normal distribution
Osteoarthritis
Pain
Patients
Physical Sciences
Population
Population studies
Proteins
Quality
Rheumatology
Stiffness
Studies
X rays
title Correlation of serum cartilage oligometric matrix protein (COMP) and interleukin-16 (IL-16) levels with disease severity in primary knee osteoarthritis: A pilot study in a Malaysian population
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