Molecular mechanisms of mucormycosis-The bitter and the sweet

[...]of the manifestation of the disease, a hallmark of mucormycosis is the ability of the causative organism to aggressively and rapidly invade blood vessels, which results in hematogenous dissemination, vessel thrombosis, and subsequent tissue necrosis [1]. [...]interactions between invading fungi...

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Bibliographic Details
Published in:PLoS pathogens 2017-08, Vol.13 (8), p.e1006408
Main Authors: Baldin, Clara, Ibrahim, Ashraf S
Format: Article
Language:English
Subjects:
Affinity
Antifungal agents
Biology and Life Sciences
Biomedical research
Blood vessels
Care and treatment
Cell membranes
Chelates
Diabetes
Diabetes therapy
Endothelial cells
Epidemics
Ferritin
Food contamination & poisoning
Fungal infections
Fungi
Genomes
Health aspects
Humans
Hyperglycemia
Immunoglobulins
Infections
Infectious diseases
Iron
Medicine and Health Sciences
Molecular mechanics
Molecular modelling
Mucormycosis
Necrosis
Organ transplantation
Pathogenesis
Pearls
Proteins
Reductases
Thromboembolism
Thrombosis
Transferrin
Transplants & implants
Virulence
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Summary:[...]of the manifestation of the disease, a hallmark of mucormycosis is the ability of the causative organism to aggressively and rapidly invade blood vessels, which results in hematogenous dissemination, vessel thrombosis, and subsequent tissue necrosis [1]. [...]interactions between invading fungi and endothelial cells lining blood vessels represent a major step in the pathogenesis of mucormycosis. Hyperglycemia can induce excessive glycosylation of proteins such as transferrin and ferritin, diminishing their iron affinity [21]. [...]in the presence of an acidotic condition due to accumulation of ketone bodies (e.g., [Beta]-hydroxy butyrate [BHB]), the low pH in the blood vessels strongly impairs the ability of transferrin to chelate iron [22]. [...]R. delemar mutants with attenuated expression of the high-affinity iron permease (Ftr1, a cell membrane protein required to transport iron intracellularly [23]) have impaired ability to take up iron from ferrioxamine, experience retarded growth on media supplemented with ferrioxamine as a sole source of iron, and demonstrate reduced virulence in mice given deferoxamine [44, 47]. [...]it is probable that the reductase/permease pathway represents a major uptake pathway for iron acquisition from ferrioxamine without internalization of the generated deferoxamine, while the uptake of the siderophore by shuttle mechanism [46] represents a secondary mechanism.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1006408