Risk of glucose intolerance and gestational diabetes mellitus in relation to maternal habitual snoring during early pregnancy

Obstructive sleep apnea (OSA) or habitual snoring is known to be associated with impaired glucose tolerance and type 2 diabetes among both men and non-pregnant women. We examined the association of habitual snoring during early pregnancy with risk of impaired glucose tolerance (IGT) and gestational...

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Bibliographic Details
Published in:PloS one 2017-09, Vol.12 (9), p.e0184966-e0184966
Main Authors: Qiu, Chunfang, Lawrence, Wayne, Gelaye, Bizu, Stoner, Lee, Frederick, Ihunnaya O, Enquobahrie, Daniel A, Sorensen, Tanya K, Williams, Michelle A
Format: Article
Language:English
Subjects:
Adult
Apnea
Biology and Life Sciences
Body mass
Body Mass Index
Body weight
Cohort Studies
Confidence intervals
Diabetes mellitus
Diabetes, Gestational - diagnosis
Diabetes, Gestational - etiology
Diagnostic systems
Epidemiology
Female
Gestational diabetes
Glucose
Glucose Intolerance - etiology
Glucose tolerance
Health risk assessment
Health risks
Humans
Intolerance
Logistic Models
Medical records
Medicine and Health Sciences
Odds Ratio
Overweight
Overweight - pathology
Physical Sciences
Pregnancy
Pregnancy Complications
Prenatal Care
Regression analysis
Regression models
Risk
Risk Factors
Sleep
Sleep disorders
Snoring - complications
Studies
Womens health
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Summary:Obstructive sleep apnea (OSA) or habitual snoring is known to be associated with impaired glucose tolerance and type 2 diabetes among both men and non-pregnant women. We examined the association of habitual snoring during early pregnancy with risk of impaired glucose tolerance (IGT) and gestational diabetes mellitus (GDM). A cohort of 1,579 women was interviewed during early pregnancy. We collected information about snoring frequency during early pregnancy. Results from screening and diagnostic tests for IGT and GDM were abstracted from medical records. Multivariate logistic regression models were fitted to estimate odds ratios (OR) and 95% confidence intervals (95% CI) of IGT and GDM associated with snoring in early pregnancy. Overall, women who snored "most or all of the time" had a 2.1-fold increased odds of IGT (OR 2.10; 95% CI 1.31-3.35) and a 2.5-fold increased odds of GDM (OR 2.50; 95% CI 1.34-4.67) as compared with women who never snored. Compared with lean women (pre-pregnancy body mass index (BMI)
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0184966