Association between perinatal hypoxic-ischemia and periventricular leukomalacia in preterm infants: A systematic review and meta-analysis

Although investigators have implicated hypoxic-ischemia (HI) as a potential cause of periventricular leukomalacia (PVL), the role of clinical risk factors or markers for HI in the development of PVL remains controversial. The aim of this study was to identify perinatal HI-related factors associated...

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Published in:PloS one 2017-09, Vol.12 (9), p.e0184993-e0184993
Main Authors: Huang, Jichong, Zhang, Li, Kang, Bingyao, Zhu, Tingting, Li, Yafei, Zhao, Fengyan, Qu, Yi, Mu, Dezhi
Format: Article
Language:English
Subjects:
Analysis
Apgar score
Apnea
Biology and Life Sciences
Birth defects
Birth weight
Cerebral palsy
Confidence intervals
Education
Female
Gynecology
Heterogeneity
Humans
Hypoxia
Hypoxia-Ischemia, Brain - complications
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases - etiology
Infants
Ischemia
Laboratories
Leukomalacia, Periventricular - etiology
Libraries
Medical ethics
Medical research
Medicine and Health Sciences
Meta-analysis
Newborn babies
Obstetrics
Pediatrics
People and Places
Periventricular leukomalacia
Physical Sciences
Placenta
Preeclampsia
Pregnancy
Premature babies
Premature infants
Research and Analysis Methods
Respiratory distress syndrome
Risk analysis
Risk Factors
Science Policy
Seizures
Seizures (Medicine)
Studies
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cited_by cdi_FETCH-LOGICAL-c692t-5c931704f43c28773aa295e6d9971607d277e8cb4f50af18ca16bbabaa4c0f403
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container_end_page e0184993
container_issue 9
container_start_page e0184993
container_title PloS one
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creator Huang, Jichong
Zhang, Li
Kang, Bingyao
Zhu, Tingting
Li, Yafei
Zhao, Fengyan
Qu, Yi
Mu, Dezhi
description Although investigators have implicated hypoxic-ischemia (HI) as a potential cause of periventricular leukomalacia (PVL), the role of clinical risk factors or markers for HI in the development of PVL remains controversial. The aim of this study was to identify perinatal HI-related factors associated with PVL. The PubMed, EMBASE, and Cochrane Library databases were searched. The last search was performed on January 2017. Summary effect estimates (pooled odds ratios [ORs]) were calculated for each risk factor using fixed or random effects models with tests for heterogeneity and publication bias. Fifteen studies with a total of 12,851 participants were included in this meta-analysis, and 14 potential risk factors were analyzed. The pooled results showed that mothers with oligohydramnios (OR, 1.55; 95% confidence interval [CI], 1.05 to 2.30), preterm infants with acidemia (OR, 1.87; 95% CI, 1.18 to 2.97), 1-minute Apgar score
doi_str_mv 10.1371/journal.pone.0184993
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The pooled results showed that mothers with oligohydramnios (OR, 1.55; 95% confidence interval [CI], 1.05 to 2.30), preterm infants with acidemia (OR, 1.87; 95% CI, 1.18 to 2.97), 1-minute Apgar score &lt;7 (OR 2.69; 95% CI, 1.13 to 6.41), 5-minute Apgar score &lt;7 (OR, 1.89; 95% CI, 1.39 to 2.56), apnea (OR, 1.76; 95% CI, 1.07 to 2.90), respiratory distress syndrome (OR, 1.46; 95% CI, 1.04 to 2.03), and seizures (OR, 4.60; 95% CI, 2.84 to 7.46) were associated with increased risk of PVL. This study identified perinatal HI-related risk factors for the development of PVL in preterm infants. Future large-scale prospective clinical studies are required to validate and extend these findings.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28931047</pmid><doi>10.1371/journal.pone.0184993</doi><tpages>e0184993</tpages><orcidid>https://orcid.org/0000-0002-9148-069X</orcidid><oa>free_for_read</oa></addata></record>
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source Publicly Available Content Database; PubMed Central
subjects Analysis
Apgar score
Apnea
Biology and Life Sciences
Birth defects
Birth weight
Cerebral palsy
Confidence intervals
Education
Female
Gynecology
Heterogeneity
Humans
Hypoxia
Hypoxia-Ischemia, Brain - complications
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases - etiology
Infants
Ischemia
Laboratories
Leukomalacia, Periventricular - etiology
Libraries
Medical ethics
Medical research
Medicine and Health Sciences
Meta-analysis
Newborn babies
Obstetrics
Pediatrics
People and Places
Periventricular leukomalacia
Physical Sciences
Placenta
Preeclampsia
Pregnancy
Premature babies
Premature infants
Research and Analysis Methods
Respiratory distress syndrome
Risk analysis
Risk Factors
Science Policy
Seizures
Seizures (Medicine)
Studies
title Association between perinatal hypoxic-ischemia and periventricular leukomalacia in preterm infants: A systematic review and meta-analysis
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