Elevated humoral response to cytomegalovirus in HIV-infected individuals with poor CD4+ T-cell immune recovery

Some HIV-infected c-ART-suppressed individuals show incomplete CD4+ T-cell recovery, abnormal T-cell activation and higher mortality. One potential source of immune activation could be coinfection with cytomegalovirus (CMV). IgG and IgM levels, immune activation, inflammation and T-cell death in c-A...

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Bibliographic Details
Published in:PloS one 2017-09, Vol.12 (9), p.e0184433-e0184433
Main Authors: Gómez-Mora, Elisabet, Massanella, Marta, García, Elisabet, Giles, David, Bernadó, Marta, Urrea, Victor, Carrillo, Jorge, Ouchi, Dan, Puig, Jordi, Negredo, Eugenia, Clotet, Bonaventura, Blanco, Julià, Cabrera, Cecilia
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
ADP-ribosyl Cyclase 1 - blood
Adult
AIDS
Anti-HIV Agents - therapeutic use
Antibodies
Antibodies, Viral - blood
Antiretroviral drugs
Apoptosis
Biology and Life Sciences
CD38 antigen
CD4 antigen
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes - immunology
CD45RA antigen
CD8 antigen
Cell activation
Cell death
Coinfection - drug therapy
Coinfection - immunology
Cytomegalovirus
Cytomegalovirus Infections - complications
Cytomegalovirus Infections - immunology
Female
Follow-Up Studies
Histocompatibility antigen HLA
HIV
HIV Infections - complications
HIV Infections - drug therapy
HIV Infections - immunology
HLA-DR Antigens - blood
Human immunodeficiency virus
Humans
Immune reconstitution
Immune response
Immune response (humoral)
Immune system
Immunoglobulin G
Immunoglobulin G - blood
Immunoglobulin M
Immunoglobulin M - blood
Immunoglobulins
Immunological memory
Inflammation - complications
Inflammation - immunology
Lymphocytes T
Male
Medicine and Health Sciences
Memory cells
Middle Aged
Morbidity
Mortality
Recovery
Recovery (Medical)
Retrospective Studies
Viral Load
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Items that cite this one
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Summary:Some HIV-infected c-ART-suppressed individuals show incomplete CD4+ T-cell recovery, abnormal T-cell activation and higher mortality. One potential source of immune activation could be coinfection with cytomegalovirus (CMV). IgG and IgM levels, immune activation, inflammation and T-cell death in c-ART-suppressed individuals with CD4+ T-cell counts >350 cells/μL (immunoconcordant, n = 133) or
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0184433