Natural course of the nodular bronchiectatic form of Mycobacterium Avium complex lung disease: Long-term radiologic change without treatment

Although the incidence of Mycobacterium avium complex (MAC) lung disease is increasing, the long-term natural course of the nodular bronchiectatic form of MAC lung disease is not well described. The objective of our study is to evaluate long-term radiologic changes in untreated MAC lung disease by a...

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Published in:PloS one 2017-10, Vol.12 (10), p.e0185774-e0185774
Main Authors: Park, Tae Yun, Chong, Semin, Jung, Jae-Woo, Park, In Won, Choi, Byoung Whui, Lim, Changwon, Lee, Chang Un, Kim, Yang Soo, Choi, Hye Won, Choi, Jae Chol
Format: Article
Language:English
Subjects:
Aged
Analysis
Biology and Life Sciences
Bronchiectasis
Bronchiectasis - diagnostic imaging
Bronchiectasis - pathology
Bronchopneumonia
Care and treatment
Chest
Computed tomography
Consolidation
Family medical history
Female
Hospitals
Humans
Infections
Internal medicine
Lung diseases
Lung Diseases - diagnostic imaging
Lung Diseases - pathology
Male
Medical imaging
Medicine
Medicine and Health Sciences
Middle Aged
Mortality
Mycobacterium avium
Mycobacterium avium complex
Mycobacterium avium-intracellulare Infection - diagnostic imaging
Mycobacterium avium-intracellulare Infection - pathology
Patients
Physical Sciences
Physiological aspects
Radiology
Research and Analysis Methods
Retrospective Studies
Risk factors
Tomography, X-Ray Computed
Variance analysis
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cited_by cdi_FETCH-LOGICAL-c692t-90dbd04e98a1cdd0802ab8895e592635fcc6544b624b3aedd4e47fe69ecd1fb43
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container_issue 10
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creator Park, Tae Yun
Chong, Semin
Jung, Jae-Woo
Park, In Won
Choi, Byoung Whui
Lim, Changwon
Lee, Chang Un
Kim, Yang Soo
Choi, Hye Won
Choi, Jae Chol
description Although the incidence of Mycobacterium avium complex (MAC) lung disease is increasing, the long-term natural course of the nodular bronchiectatic form of MAC lung disease is not well described. The objective of our study is to evaluate long-term radiologic changes in untreated MAC lung disease by analyzing serial chest computed tomography (CT) scan findings. Of 104 patients with MAC lung disease, we selected 40 untreated nodular bronchiectatic MAC patients who underwent serial chest CTs without treatment for at least four years (mean = 6.23 years). Majority of patients have minimal symptoms. Two chest radiologists retrospectively reviewed initial and final chest CT scans. Each chest CT scan was scored for presence and extent of bronchiectasis, cellular bronchiolitis, consolidation, cavity, and nodule (maximum score: 30). Of 40 patients, 39 (97.5%) experienced a significant increase in overall CT score (overall difference = 4.89, p
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The objective of our study is to evaluate long-term radiologic changes in untreated MAC lung disease by analyzing serial chest computed tomography (CT) scan findings. Of 104 patients with MAC lung disease, we selected 40 untreated nodular bronchiectatic MAC patients who underwent serial chest CTs without treatment for at least four years (mean = 6.23 years). Majority of patients have minimal symptoms. Two chest radiologists retrospectively reviewed initial and final chest CT scans. Each chest CT scan was scored for presence and extent of bronchiectasis, cellular bronchiolitis, consolidation, cavity, and nodule (maximum score: 30). Of 40 patients, 39 (97.5%) experienced a significant increase in overall CT score (overall difference = 4.89, p&lt;0.001). On repeated measure analysis of variance analysis, cavity yielded the largest increase compared with cellular bronchiolitis (p = 0.013), nodule (p&lt;0.001), and consolidation (p = 0.004). However, there was no significant difference in mean score change between cavity and bronchiectasis (p = 0.073). In analysis between radiologic parameters and the absolute number of involved segments, bronchiectasis showed most significant change compared with nodule (p&lt;0.001) and consolidation (p&lt;0.001). Most untreated nodular bronchiectatic MAC lung disease cases showed radiologic deterioration over long-term observation periods when we compared serial chest CT scans. 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The objective of our study is to evaluate long-term radiologic changes in untreated MAC lung disease by analyzing serial chest computed tomography (CT) scan findings. Of 104 patients with MAC lung disease, we selected 40 untreated nodular bronchiectatic MAC patients who underwent serial chest CTs without treatment for at least four years (mean = 6.23 years). Majority of patients have minimal symptoms. Two chest radiologists retrospectively reviewed initial and final chest CT scans. Each chest CT scan was scored for presence and extent of bronchiectasis, cellular bronchiolitis, consolidation, cavity, and nodule (maximum score: 30). Of 40 patients, 39 (97.5%) experienced a significant increase in overall CT score (overall difference = 4.89, p&lt;0.001). On repeated measure analysis of variance analysis, cavity yielded the largest increase compared with cellular bronchiolitis (p = 0.013), nodule (p&lt;0.001), and consolidation (p = 0.004). However, there was no significant difference in mean score change between cavity and bronchiectasis (p = 0.073). In analysis between radiologic parameters and the absolute number of involved segments, bronchiectasis showed most significant change compared with nodule (p&lt;0.001) and consolidation (p&lt;0.001). Most untreated nodular bronchiectatic MAC lung disease cases showed radiologic deterioration over long-term observation periods when we compared serial chest CT scans. Careful monitoring of MAC lung disease with serial chest CT scan can be beneficial in these untreated patients.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28968457</pmid><doi>10.1371/journal.pone.0185774</doi><tpages>e0185774</tpages><oa>free_for_read</oa></addata></record>
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1932-6203
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subjects Aged
Analysis
Biology and Life Sciences
Bronchiectasis
Bronchiectasis - diagnostic imaging
Bronchiectasis - pathology
Bronchopneumonia
Care and treatment
Chest
Computed tomography
Consolidation
Family medical history
Female
Hospitals
Humans
Infections
Internal medicine
Lung diseases
Lung Diseases - diagnostic imaging
Lung Diseases - pathology
Male
Medical imaging
Medicine
Medicine and Health Sciences
Middle Aged
Mortality
Mycobacterium avium
Mycobacterium avium complex
Mycobacterium avium-intracellulare Infection - diagnostic imaging
Mycobacterium avium-intracellulare Infection - pathology
Patients
Physical Sciences
Physiological aspects
Radiology
Research and Analysis Methods
Retrospective Studies
Risk factors
Tomography, X-Ray Computed
Variance analysis
title Natural course of the nodular bronchiectatic form of Mycobacterium Avium complex lung disease: Long-term radiologic change without treatment
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