Outbreaks of epidemic keratoconjunctivitis caused by human adenovirus type 8 in the Tibet Autonomous Region of China in 2016

From April to November 2016, two outbreaks of epidemic keratoconjunctivitis (EKC) occurred successively at primary and middle schools in the Tibet Autonomous Region of China, and a total of 197 clinically diagnosed cases were reported. Real-time PCR analyses confirmed that human adenovirus (HAdV) in...

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Bibliographic Details
Published in:PloS one 2017-09, Vol.12 (9), p.e0185048-e0185048
Main Authors: Lei, Zhenqiang, Zhu, Zhen, Wang, Bai Ma Ci, Mei, Hong, Li, Hong, Ga, Dan Zeng Gong, Jie, Guo, Chi, Mi Ma Bu, Zhang, Sheng, Ma, Chaofeng, Xu, Wenbo
Format: Article
Language:English
Subjects:
Adenovirus Infections, Human - epidemiology
Adenoviruses
Adenoviruses, Human
Analysis
Biology and Life Sciences
Causes of
Cell Line
China
Computer and Information Sciences
Conjunctivitis, Viral - epidemiology
Conjunctivitis, Viral - virology
Dietary fiber
Disease control
Disease Outbreaks
Disease prevention
Distribution
Epidemic keratoconjunctivitis
Epidemics
Female
Genomes
Health aspects
Health surveillance
Humans
Infectious diseases
Keratoconjunctivitis
Laboratories
Male
Measles
Medicine and Health Sciences
Methods
Outbreaks
People and Places
Phylogeny
Physiological aspects
Public health
Research and Analysis Methods
Rubella
Schools
Social Sciences
Tibet - epidemiology
Virology
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Summary:From April to November 2016, two outbreaks of epidemic keratoconjunctivitis (EKC) occurred successively at primary and middle schools in the Tibet Autonomous Region of China, and a total of 197 clinically diagnosed cases were reported. Real-time PCR analyses confirmed that human adenovirus (HAdV) infection was related to these outbreaks. Further studies involving sequence determination and phylogenetic analysis based on the penton base, hexon, and fiber genes indicated that human adenovirus type 8 (HAdV-8), belonging to species D, was responsible for the outbreaks. This is the first report of a HAdV-8 associated EKC outbreak in mainland of China, and the results of this study are expected to provide support for future research into HAdV-8 in China.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0185048