Evidence for active maintenance of inverted repeat structures identified by a comparative genomic approach

Inverted repeats have been found to occur in both prokaryotic and eukaryotic genomes. Usually they are short and some have important functions in various biological processes. However, long inverted repeats are rare and can cause genome instability. Analyses of C. elegans genome identified long, nea...

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Bibliographic Details
Published in:PloS one 2007-02, Vol.2 (2), p.e262-e262
Main Authors: Zhao, Guoyan, Chang, Kuan Y, Varley, Katherine, Stormo, Gary D
Format: Article
Language:English
Subjects:
Animals
Biological activity
Caenorhabditis - genetics
Caenorhabditis briggsae
Caenorhabditis elegans
Caenorhabditis elegans - genetics
Cephalodella remanei
Chromosomes
Comparative analysis
Comparative Genomic Hybridization
Computational Biology/Comparative Sequence Analysis
DNA, Helminth - genetics
DNA, Intergenic - genetics
Evolution, Molecular
Gene Duplication
Gene sequencing
Genes
Genetic recombination
Genetic Speciation
Genetics and Genomics/Comparative Genomics
Genomes
Genomic Instability
Genomics
Homology
Inverted repeat
Inverted Repeat Sequences - genetics
Nematodes
Phylogeny
Saccharomyces cerevisiae
Sequence Alignment
Sequence Homology, Nucleic Acid
Species Specificity
Stability
Stability analysis
Yeast
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Summary:Inverted repeats have been found to occur in both prokaryotic and eukaryotic genomes. Usually they are short and some have important functions in various biological processes. However, long inverted repeats are rare and can cause genome instability. Analyses of C. elegans genome identified long, nearly-perfect inverted repeat sequences involving both divergently and convergently oriented homologous gene pairs and complete intergenic sequences. Comparisons with the orthologous regions from the genomes of C. briggsae and C. remanei show that the inverted repeat structures are often far more conserved than the sequences. This observation implies that there is an active mechanism for maintaining the inverted repeat nature of the sequences.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0000262