CA 19-9 and CA 125 as potential predictors of disease recurrence in resectable lung adenocarcinoma

• Published in: PloS one 2017-10, Vol.12 (10), p.e0186284-e0186284
• Main Authors: Isaksson, Sofi, Jönsson, Per, Monsef, Nastaran, Brunnström, Hans, Bendahl, Pär-Ola, Jönsson, Mats, Staaf, Johan, Planck, Maria
• Format: Article
• Language: English
• Subjects: Adenocarcinoma; Adenocarcinoma - immunology; Adenocarcinoma - pathology; Adenocarcinoma - surgery; Adenocarcinoma of Lung; Aged; Analysis; Antigens; Biological markers; Biomarkers; Biomarkers, Tumor; CA-125 Antigen; CA-19-9 Antigen; Cancer; Cancer and Oncology; Cancer och onkologi; Cancer recurrence; Carbohydrates; Carcinoembryonic antigen; Care and treatment; Charts; Classification; Clinical Medicine; Confidence intervals; Diagnosis; Epidermal growth factor; Epididymis; Female; Genetic aspects; Glycoproteins; Health aspects; Histology; Humans; Klinisk medicin; Lung cancer; Lung diseases; Lung Neoplasms - immunology; Lung Neoplasms - pathology; Lung Neoplasms - surgery; Male; Markers; Medical and Health Sciences; Medical diagnosis; Medical prognosis; Medical treatment; Medicin och hälsovetenskap; Medicine and Health Sciences; Metastasis; Middle Aged; Mutation; Non-small cell lung carcinoma; Oncology; Ovarian cancer; Pathology; Patient outcomes; Patients; Phosphopyruvate hydratase; Proteins; Recurrence; Retrospective Studies; Risk factors; Sampling methods; Studies; Surgery; Thoracic surgery; Tumor markers; Tumors
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0186284

Among patients who underwent primary surgery for non-small cell lung cancer (NSCLC), recurrent disease is frequent and cannot be accurately predicted solely from TNM stage and histopathological features. The aim of this study was to examine the association of tumor markers in pre-operative serum with recurrent disease. Blood samples were collected prior to lung cancer surgery from 107 patients with stage I-III lung adenocarcinoma surgically treated at Lund University hospital, Lund, Sweden, between 2005 and 2011. The serum tumor markers Carcinoembryonic antigen (CEA), Neuron-specific enolase (NSE), Cancer antigen 125 (CA 125), Human epididymis protein 4 (HE4) and Carbohydrate antigen (CA 19-9) were analyzed retrospectively and clinical follow-up data were collected from patient charts. Forty (37%) patients were diagnosed with recurrent disease. Sixty-eight (64%) patients had at least one elevated tumor marker prior to surgery. In analysis of disease-free survival (DFS), CA 125 and/or CA 19-9 were significantly associated with recurrent disease adjusted to stage and adjuvant treatment (hazard ratio 2.8, 95% confidence interval 1.4-5.7, p = 0.006). High pre-operative serum CA 19-9 and/or CA 125 might indicate an increased incidence of recurrent disease in resectable lung adenocarcinomas.