Prevalence, risk factors, and virulence genes of Helicobacter pylori among dyspeptic patients in two different gastric cancer risk regions of Thailand

• Published in: PloS one 2017-10, Vol.12 (10), p.e0187113-e0187113
• Main Authors: Subsomwong, Phawinee, Miftahussurur, Muhammad, Uchida, Tomohisa, Vilaichone, Ratha-Korn, Ratanachu-Ek, Thawee, Mahachai, Varocha, Yamaoka, Yoshio
• Format: Article
• Language: English
• Subjects: Alcoholic beverages; Amino acids; Cancer; Causes of; Cross-Sectional Studies; Demographics; Diagnosis; Disease; Disease prevention; Epidemiology; Gastric cancer; Gastric Mucosa - metabolism; Gastric Mucosa - microbiology; Gastroenterology; Genes; Genes, Bacterial; Genetic aspects; Genotype; Genotypes; Health risks; Helicobacter infections; Helicobacter Infections - complications; Helicobacter Infections - epidemiology; Helicobacter Infections - microbiology; Helicobacter pylori; Helicobacter pylori - genetics; Helicobacter pylori - pathogenicity; Hepatology; Histology; Hospitals; Humans; Incidence; Infections; Interleukin-8 - biosynthesis; Kinases; Patients; Prevalence; Preventive medicine; Risk analysis; Risk Factors; Stomach cancer; Stomach Neoplasms - complications; Stomach Neoplasms - epidemiology; Strains (organisms); Thailand - epidemiology; Ulcers; University faculty; Virulence; Virulence - genetics
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0187113

Gastric cancer risk is varied among different regions of Thailand. We examined the characteristics of Helicobacter pylori infection in two regions of Thailand. The H. pylori status of 273 dyspeptic patients (136 from the South and 137 from the North; a low and high incidence of gastric cancer region, respectively) was evaluated, and virulence genotypes (cagA, vacA, hrgA and jhp0562-positive/β-(1,3)galT) were determined. The overall H. pylori infection rate was 34.1% (93/273). The prevalence was higher in the North than in the South (50.4% vs. 17.6%, P