Impact of lean mass and bone density on glomerular filtration rate estimation in people living with HIV/AIDS

Chronic kidney disease is a frequent complication in persons living with HIV/AIDS. Although previous studies have suggested that the CKD-EPI formula is appropriate to estimate glomerular filtration rate (GFR) in HIV-positive adults with normal kidney function, the optimal way to estimate GFR in thos...

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Published in:PloS one 2017-11, Vol.12 (11), p.e0186410-e0186410
Main Authors: Isnard Bagnis, Corinne, Pieroni, Laurence, Inaoui, Rachida, Maksud, Philippe, Lallauret, Stéphanie, Valantin, Marc-Antoine, Tubiana, Roland, Katlama, Christine, Deray, Gilbert, Courbebaisse, Marie, Tourret, Jérôme, Tezenas du Montcel, Sophie
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Acquired immune deficiency syndrome
Adults
Aged
AIDS
Biology and Life Sciences
Body Composition
Body mass
Bone Density
Bone mass
CD4 antigen
Chronic kidney failure
Creatinine
Cross-Sectional Studies
Cystatin C
Diabetes mellitus
Diagnosis
Diagnostic systems
Drug dosages
Dual energy X-ray absorptiometry
Ethylenediaminetetraacetic acids
Female
Glomerular Filtration Rate
Health aspects
HIV
HIV Infections - physiopathology
HIV patients
Human immunodeficiency virus
Humans
Hypertension
Kidney transplantation
Life Sciences
Male
Medical diagnosis
Medicine and Health Sciences
Middle Aged
Patients
Risk factors
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Summary:Chronic kidney disease is a frequent complication in persons living with HIV/AIDS. Although previous studies have suggested that the CKD-EPI formula is appropriate to estimate glomerular filtration rate (GFR) in HIV-positive adults with normal kidney function, the optimal way to estimate GFR in those with Stage 3 chronic kidney disease is not known. Moreover, the impact of muscle mass on creatinine level and GFR estimation is unknown. Our study aimed to evaluate the accuracy of different diagnostic tests available compared to the gold standard measurement of GFR. A group of 44 HIV-1 patients with an estimated GFR between 60 and 30 ml/min/1.73 m2 were included in a single-center cross-sectional study. Serum creatinine and cystatin C were measured. GFR was estimated using Cockcroft-Gault, MDRD, sMDRD, CKD-EPI, CKD-EPIcyst, and CKD-EPIcyst/creat formulae and was measured using isotopic Chrome51 EDTA clearance. Bone density and muscle mass were measured by DXA scan. Mean age was 62±10 years. Mean BMI was 23±4 kg/m2. Prevalence of diabetes was 30% and of hypertension was 47%. Viral load was
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0186410