Prevalence of extracranial carotid artery aneurysms in patients with an intracranial aneurysm

• Published in: PloS one 2017-11, Vol.12 (11), p.e0187479-e0187479
• Main Authors: Pourier, V E C, van Laarhoven, C J H C M, Vergouwen, M D I, Rinkel, G J E, de Borst, Gert J
• Format: Article
• Language: English
• Subjects: Aneurysm; Aneurysms; Arteries; Biology and Life Sciences; Brain; Care and treatment; Carotid arteries; Carotid artery; Carotid artery diseases; Complications and side effects; Data bases; Diagnosis; Genetic factors; Health care facilities; Hemorrhage; Intracranial aneurysms; Medical imaging; Medicine and Health Sciences; Neuroimaging; Patients; Prevalence studies (Epidemiology); Research and Analysis Methods; Risk factors; Saccule; Subarachnoid hemorrhage; Veins & arteries; Vertebrae
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0187479

Aneurysms in various arterial beds have common risk- and genetic factors. Data on the correlation of extracranial carotid artery aneurysms (ECAA) with aneurysms in other vascular territories are lacking. We aimed to investigate the prevalence of ECAA in patients with an intracranial aneurysm (IA). We used prospectively collected databases of consecutive patients registered at the University Medical Center Utrecht with an unruptured intracranial aneurysm (UIA) or aneurysmal Subarachnoid hemorrhage (SAH). The medical files of patients included in both databases were screened for availability of radiological reports, imaging of the brain and of the cervical carotid arteries. All available radiological images were then reviewed primarily for the presence of an ECAA and secondarily for an extradural/cavernous carotid or vertebral artery aneurysm. An ECAA was defined as a fusiform dilation ≥150% of the normal internal or common carotid artery or a saccular distention of any size. We screened 4465 patient records (SAH database n = 3416, UIA database n = 1049), of which 2931 had radiological images of the carotid arteries available. An ECAA was identified in 12/638 patients (1.9%; 95% CI 1.1-3.3) with completely imaged carotid arteries and in 15/2293 patients (0.7%; 95% CI 0.4-1.1) with partially depicted carotid arteries. Seven out of 27 patients had an additional extradural (cavernous or vertebral artery) aneurysm. This comprehensive study suggests a prevalence for ECAA of approximately 2% of patients with an IA. The rarity of the disease makes screening unnecessary so far. Future registry studies should study the factors associated with IA and ECAA to estimate the prevalence of ECAA in these young patients more accurately.