Distinct T and NK cell populations may serve as immune correlates of protection against symptomatic pandemic influenza A(H1N1) virus infection during pregnancy

Maternal influenza infection during pregnancy is associated with increased risk of morbidity and mortality. However, the link between the anti-influenza immune responses and health-related risks during infection is not well understood. We have analyzed memory T and NK cell mediated immunity (CMI) re...

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Bibliographic Details
Published in:PloS one 2017-11, Vol.12 (11), p.e0188055-e0188055
Main Authors: Savic, Miloje, Dembinski, Jennifer L, Laake, Ida, Hungnes, Olav, Cox, Rebecca, Oftung, Fredrik, Trogstad, Lill, Mjaaland, Siri
Format: Article
Language:English
Subjects:
Antigens
Biological properties
Biological samples
Biology and Life Sciences
CCR7 protein
CD3 antigen
CD4 antigen
CD45RA antigen
CD7 antigen
CD8 antigen
CD95 antigen
Correlation
Cytokines
Development and progression
Disease control
Environmental health
Enzyme-linked immunosorbent assay
Epitopes
Fever
Flow cytometry
Health aspects
Health risks
Hemagglutination inhibition
Illnesses
Immune response
Immunity
Immunization
Immunological memory
Infections
Infectious diseases
Influenza
Influenza A
Interleukin 2
Killer cells
Libraries
Lymphocytes
Lymphocytes T
Medicine and Health Sciences
Memory cells
Methods
Morbidity
Mortality
Natural killer cells
Pandemics
Peripheral blood mononuclear cells
Physiological aspects
Populations
Pregnancy
Pregnant women
Public health
R&D
Research & development
Swine flu
T cell receptors
T cells
Tumor necrosis factor-α
Vaccines
Viruses
Womens health
γ-Interferon
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Summary:Maternal influenza infection during pregnancy is associated with increased risk of morbidity and mortality. However, the link between the anti-influenza immune responses and health-related risks during infection is not well understood. We have analyzed memory T and NK cell mediated immunity (CMI) responses in pandemic influenza A(H1N1)pdm09 (pdm09) virus infected non-vaccinated pregnant women participating in the Norwegian Influenza Pregnancy Cohort (NorFlu). The cohort includes information on immunization, self-reported health and disease status, and biological samples (plasma and PBMC). Infected cases (N = 75) were defined by having a serum hemagglutination inhibition (HI) titer > = 20 to influenza pdm09 virus at the time of delivery, while controls (N = 75) were randomly selected among non-infected pregnant women (HI titer
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0188055