Supine posture changes lung volumes and increases ventilation heterogeneity in cystic fibrosis

Lung Clearance Index (LCI) is recognised as an early marker of cystic fibrosis (CF) lung disease. The effect of posture on LCI however is important when considering longitudinal measurements from infancy and when comparing LCI to imaging studies. 35 children with CF and 28 healthy controls (HC) were...

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Bibliographic Details
Published in:PloS one 2017-11, Vol.12 (11), p.e0188275-e0188275
Main Authors: Smith, Laurie J, Macleod, Kenneth A, Collier, Guilhem J, Horn, Felix C, Sheridan, Helen, Aldag, Ina, Taylor, Chris J, Cunningham, Steve, Wild, Jim M, Horsley, Alex
Format: Article
Language:English
Subjects:
Alveoli
Biology and Life Sciences
Care and treatment
Case-Control Studies
Child
Children
Cystic fibrosis
Cystic Fibrosis - pathology
Cystic Fibrosis - physiopathology
Diagnosis
Female
Functional Residual Capacity
Health screening
Heterogeneity
Humans
Longitudinal studies
Lung - pathology
Lung - physiopathology
Lung diseases
Lungs
Male
Medical imaging
Medicine and Health Sciences
Methods
Neurosciences
NMR
Nuclear magnetic resonance
Organ Size
Physiology
Posture
Pulmonary Alveoli - pathology
Pulmonary Alveoli - physiopathology
Pulmonary Ventilation
Research and Analysis Methods
Respiratory diseases
Supine Position
Tomography
Ventilation
Ventilators
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Summary:Lung Clearance Index (LCI) is recognised as an early marker of cystic fibrosis (CF) lung disease. The effect of posture on LCI however is important when considering longitudinal measurements from infancy and when comparing LCI to imaging studies. 35 children with CF and 28 healthy controls (HC) were assessed. Multiple breath washout (MBW) was performed both sitting and supine in triplicate and analysed for LCI, Scond, Sacin, and lung volumes. These values were also corrected for the Fowler dead-space to create 'alveolar' indices. From sitting to supine there was a significant increase in LCI and a significant decrease in FRC for both CF and HC (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0188275