Loading…
Bisphosphonates and risk of upper gastrointestinal cancer--a case control study using the General Practice Research Database (GPRD)
Concerns have been raised as to the safety of bisphosphonates; in particular a possible link between bisphosphonate use and upper gastrointestinal (GI) cancer. Two published studies using different study populations but drawn from earlier versions of the same national UK database, reached differing...
Saved in:
| Published in: | PloS one 2012-10, Vol.7 (10), p.e47616 |
|---|---|
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c692t-8ed4c18becaed496c2f1787916e6b5cd467a156161c53774e526480298e416db3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c692t-8ed4c18becaed496c2f1787916e6b5cd467a156161c53774e526480298e416db3 |
| container_end_page | |
| container_issue | 10 |
| container_start_page | e47616 |
| container_title | PloS one |
| container_volume | 7 |
| creator | Wright, Ellen Schofield, Peter T Seed, Paul Molokhia, Mariam |
| description | Concerns have been raised as to the safety of bisphosphonates; in particular a possible link between bisphosphonate use and upper gastrointestinal (GI) cancer. Two published studies using different study populations but drawn from earlier versions of the same national UK database, reached differing conclusions: one finding no evidence for an increase in the risk of gastric or oesophageal cancer in bisphosphonate users and one finding a small but significantly increased risk of oesophageal cancer linked to duration of bisphosphonate use.
Design-A case control study comparing bisphosphonate prescribing in cases of upper GI cancer from 1995 to 2007 using UK primary care electronic health records (GPRD). Main Outcome Measure-Relative Risk (approximated to Odds Ratio for rare events) for oesophageal and gastric cancer development in bisphosphonate users compared to non-users. The odds of being a case of oesophageal cancer, adjusted for smoking status, were significantly increased in women who had had one or more bisphosphonate prescriptions, odds ratio 1.54 (95% CI 1.27-1.88) compared to non-users. There was no significant effect on gastric cancer in women, odds ratio adjusted for smoking status, 1.06 (95% CI 0.83-1.37) and also no apparent risk in men for either oesophageal or gastric cancer, odds ratio adjusted for smoking status 0.78 (95%CI 0.56-1.09) and 0.87 (95% CI 0.55-1.36) respectively.
Our results support a small but significant increased risk of oesophageal cancer in women prescribed bisphosphonates and is based on the largest number of exposed cases to date in the UK. |
| doi_str_mv | 10.1371/journal.pone.0047616 |
| format | article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1970314219</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A477045714</galeid><doaj_id>oai_doaj_org_article_c8b7a9d01cbb47c3a3f62d51f6784488</doaj_id><sourcerecordid>A477045714</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-8ed4c18becaed496c2f1787916e6b5cd467a156161c53774e526480298e416db3</originalsourceid><addsrcrecordid>eNqNk12L1DAUhoso7jr6D0QDgrgXHZsmTdqbhXVXx4GFXcaP25Cmp23WTjImrbjX_nFTp7tMQUFK6CHnOW9O3_RE0XOcLDHh-O2NHZyR3XJnDSyThHKG2YPoGBckjVmakIcH8VH0xPubJMlIztjj6CglGKd5mh1Hv95pv2vtuIzswSNpKuS0_4ZsjYbdDhxqpO-d1SZkex1OREoaBS6OZYg8IGVNyHfI90N1iwavTYP6FtAKDLiAXzupeq0AbcCDdKpFF7KX5Vj6ZnW9uTh5Gj2qZefh2fReRF8-vP98_jG-vFqtz88uY8WKtI9zqKjCeQlKhqhgKq0xz3mBGbAyUxVlXOIsuIBVRjinkKWM5kla5EAxq0qyiF7udXed9WLyzwtc8IRgmga3FtF6T1RW3oid01vpboWVWvzZsK4R0oVv6UCovOSyqBKsypJyRSSpWVpluGY8pzTPg9bpdNpQbqFSEFyS3Ux0njG6FY39IUhomuJR4NUk4Oz3IZj_j5YnqpGhK21qG8TUVnslzijnCc04poFa_oUKTwVbHS4Qah32ZwUns4LxkuFn38jBe7H-tPl_9urrnH19wLYgu771tht6bY2fg3QPKme9d1DfO4cTMQ7AnRtiHAAxDUAoe3Ho-n3R3R9PfgMyOgDj</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1970314219</pqid></control><display><type>article</type><title>Bisphosphonates and risk of upper gastrointestinal cancer--a case control study using the General Practice Research Database (GPRD)</title><source>PubMed (Medline)</source><source>Publicly Available Content (ProQuest)</source><creator>Wright, Ellen ; Schofield, Peter T ; Seed, Paul ; Molokhia, Mariam</creator><contributor>Hold, Georgina L.</contributor><creatorcontrib>Wright, Ellen ; Schofield, Peter T ; Seed, Paul ; Molokhia, Mariam ; Hold, Georgina L.</creatorcontrib><description>Concerns have been raised as to the safety of bisphosphonates; in particular a possible link between bisphosphonate use and upper gastrointestinal (GI) cancer. Two published studies using different study populations but drawn from earlier versions of the same national UK database, reached differing conclusions: one finding no evidence for an increase in the risk of gastric or oesophageal cancer in bisphosphonate users and one finding a small but significantly increased risk of oesophageal cancer linked to duration of bisphosphonate use.
Design-A case control study comparing bisphosphonate prescribing in cases of upper GI cancer from 1995 to 2007 using UK primary care electronic health records (GPRD). Main Outcome Measure-Relative Risk (approximated to Odds Ratio for rare events) for oesophageal and gastric cancer development in bisphosphonate users compared to non-users. The odds of being a case of oesophageal cancer, adjusted for smoking status, were significantly increased in women who had had one or more bisphosphonate prescriptions, odds ratio 1.54 (95% CI 1.27-1.88) compared to non-users. There was no significant effect on gastric cancer in women, odds ratio adjusted for smoking status, 1.06 (95% CI 0.83-1.37) and also no apparent risk in men for either oesophageal or gastric cancer, odds ratio adjusted for smoking status 0.78 (95%CI 0.56-1.09) and 0.87 (95% CI 0.55-1.36) respectively.
Our results support a small but significant increased risk of oesophageal cancer in women prescribed bisphosphonates and is based on the largest number of exposed cases to date in the UK.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0047616</identifier><identifier>PMID: 23112825</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Alcohol use ; Alendronate - adverse effects ; Bisphosphonates ; Bone Density Conservation Agents - adverse effects ; Cancer ; Cancer research ; Case-Control Studies ; Confidence intervals ; Databases, Factual ; Development and progression ; Diphosphonates - adverse effects ; Electronic health records ; Electronic medical records ; Esophageal cancer ; Esophageal Neoplasms - chemically induced ; Esophagus ; Esophagus - drug effects ; Family medicine ; Female ; Gastric cancer ; Gastrointestinal cancer ; Gastrointestinal Neoplasms - chemically induced ; Health care ; Health risk assessment ; Health risks ; Health sciences ; Hormone replacement therapy ; Humans ; Intestines - drug effects ; Male ; Medical diagnosis ; Medicine ; Middle Aged ; Osteoporosis ; Phosphonates ; Population studies ; Practice research ; Primary care ; Public health ; Risk ; Risk Factors ; Smoking ; Stomach - drug effects ; Stomach cancer ; Studies ; Systematic review</subject><ispartof>PloS one, 2012-10, Vol.7 (10), p.e47616</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Wright et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2012 Wright et al 2012 Wright et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-8ed4c18becaed496c2f1787916e6b5cd467a156161c53774e526480298e416db3</citedby><cites>FETCH-LOGICAL-c692t-8ed4c18becaed496c2f1787916e6b5cd467a156161c53774e526480298e416db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1970314219/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1970314219?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23112825$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Hold, Georgina L.</contributor><creatorcontrib>Wright, Ellen</creatorcontrib><creatorcontrib>Schofield, Peter T</creatorcontrib><creatorcontrib>Seed, Paul</creatorcontrib><creatorcontrib>Molokhia, Mariam</creatorcontrib><title>Bisphosphonates and risk of upper gastrointestinal cancer--a case control study using the General Practice Research Database (GPRD)</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Concerns have been raised as to the safety of bisphosphonates; in particular a possible link between bisphosphonate use and upper gastrointestinal (GI) cancer. Two published studies using different study populations but drawn from earlier versions of the same national UK database, reached differing conclusions: one finding no evidence for an increase in the risk of gastric or oesophageal cancer in bisphosphonate users and one finding a small but significantly increased risk of oesophageal cancer linked to duration of bisphosphonate use.
Design-A case control study comparing bisphosphonate prescribing in cases of upper GI cancer from 1995 to 2007 using UK primary care electronic health records (GPRD). Main Outcome Measure-Relative Risk (approximated to Odds Ratio for rare events) for oesophageal and gastric cancer development in bisphosphonate users compared to non-users. The odds of being a case of oesophageal cancer, adjusted for smoking status, were significantly increased in women who had had one or more bisphosphonate prescriptions, odds ratio 1.54 (95% CI 1.27-1.88) compared to non-users. There was no significant effect on gastric cancer in women, odds ratio adjusted for smoking status, 1.06 (95% CI 0.83-1.37) and also no apparent risk in men for either oesophageal or gastric cancer, odds ratio adjusted for smoking status 0.78 (95%CI 0.56-1.09) and 0.87 (95% CI 0.55-1.36) respectively.
Our results support a small but significant increased risk of oesophageal cancer in women prescribed bisphosphonates and is based on the largest number of exposed cases to date in the UK.</description><subject>Aged</subject><subject>Alcohol use</subject><subject>Alendronate - adverse effects</subject><subject>Bisphosphonates</subject><subject>Bone Density Conservation Agents - adverse effects</subject><subject>Cancer</subject><subject>Cancer research</subject><subject>Case-Control Studies</subject><subject>Confidence intervals</subject><subject>Databases, Factual</subject><subject>Development and progression</subject><subject>Diphosphonates - adverse effects</subject><subject>Electronic health records</subject><subject>Electronic medical records</subject><subject>Esophageal cancer</subject><subject>Esophageal Neoplasms - chemically induced</subject><subject>Esophagus</subject><subject>Esophagus - drug effects</subject><subject>Family medicine</subject><subject>Female</subject><subject>Gastric cancer</subject><subject>Gastrointestinal cancer</subject><subject>Gastrointestinal Neoplasms - chemically induced</subject><subject>Health care</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Health sciences</subject><subject>Hormone replacement therapy</subject><subject>Humans</subject><subject>Intestines - drug effects</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Osteoporosis</subject><subject>Phosphonates</subject><subject>Population studies</subject><subject>Practice research</subject><subject>Primary care</subject><subject>Public health</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Smoking</subject><subject>Stomach - drug effects</subject><subject>Stomach cancer</subject><subject>Studies</subject><subject>Systematic review</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7jr6D0QDgrgXHZsmTdqbhXVXx4GFXcaP25Cmp23WTjImrbjX_nFTp7tMQUFK6CHnOW9O3_RE0XOcLDHh-O2NHZyR3XJnDSyThHKG2YPoGBckjVmakIcH8VH0xPubJMlIztjj6CglGKd5mh1Hv95pv2vtuIzswSNpKuS0_4ZsjYbdDhxqpO-d1SZkex1OREoaBS6OZYg8IGVNyHfI90N1iwavTYP6FtAKDLiAXzupeq0AbcCDdKpFF7KX5Vj6ZnW9uTh5Gj2qZefh2fReRF8-vP98_jG-vFqtz88uY8WKtI9zqKjCeQlKhqhgKq0xz3mBGbAyUxVlXOIsuIBVRjinkKWM5kla5EAxq0qyiF7udXed9WLyzwtc8IRgmga3FtF6T1RW3oid01vpboWVWvzZsK4R0oVv6UCovOSyqBKsypJyRSSpWVpluGY8pzTPg9bpdNpQbqFSEFyS3Ux0njG6FY39IUhomuJR4NUk4Oz3IZj_j5YnqpGhK21qG8TUVnslzijnCc04poFa_oUKTwVbHS4Qah32ZwUns4LxkuFn38jBe7H-tPl_9urrnH19wLYgu771tht6bY2fg3QPKme9d1DfO4cTMQ7AnRtiHAAxDUAoe3Ho-n3R3R9PfgMyOgDj</recordid><startdate>20121024</startdate><enddate>20121024</enddate><creator>Wright, Ellen</creator><creator>Schofield, Peter T</creator><creator>Seed, Paul</creator><creator>Molokhia, Mariam</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20121024</creationdate><title>Bisphosphonates and risk of upper gastrointestinal cancer--a case control study using the General Practice Research Database (GPRD)</title><author>Wright, Ellen ; Schofield, Peter T ; Seed, Paul ; Molokhia, Mariam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-8ed4c18becaed496c2f1787916e6b5cd467a156161c53774e526480298e416db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Alcohol use</topic><topic>Alendronate - adverse effects</topic><topic>Bisphosphonates</topic><topic>Bone Density Conservation Agents - adverse effects</topic><topic>Cancer</topic><topic>Cancer research</topic><topic>Case-Control Studies</topic><topic>Confidence intervals</topic><topic>Databases, Factual</topic><topic>Development and progression</topic><topic>Diphosphonates - adverse effects</topic><topic>Electronic health records</topic><topic>Electronic medical records</topic><topic>Esophageal cancer</topic><topic>Esophageal Neoplasms - chemically induced</topic><topic>Esophagus</topic><topic>Esophagus - drug effects</topic><topic>Family medicine</topic><topic>Female</topic><topic>Gastric cancer</topic><topic>Gastrointestinal cancer</topic><topic>Gastrointestinal Neoplasms - chemically induced</topic><topic>Health care</topic><topic>Health risk assessment</topic><topic>Health risks</topic><topic>Health sciences</topic><topic>Hormone replacement therapy</topic><topic>Humans</topic><topic>Intestines - drug effects</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medicine</topic><topic>Middle Aged</topic><topic>Osteoporosis</topic><topic>Phosphonates</topic><topic>Population studies</topic><topic>Practice research</topic><topic>Primary care</topic><topic>Public health</topic><topic>Risk</topic><topic>Risk Factors</topic><topic>Smoking</topic><topic>Stomach - drug effects</topic><topic>Stomach cancer</topic><topic>Studies</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wright, Ellen</creatorcontrib><creatorcontrib>Schofield, Peter T</creatorcontrib><creatorcontrib>Seed, Paul</creatorcontrib><creatorcontrib>Molokhia, Mariam</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wright, Ellen</au><au>Schofield, Peter T</au><au>Seed, Paul</au><au>Molokhia, Mariam</au><au>Hold, Georgina L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bisphosphonates and risk of upper gastrointestinal cancer--a case control study using the General Practice Research Database (GPRD)</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-10-24</date><risdate>2012</risdate><volume>7</volume><issue>10</issue><spage>e47616</spage><pages>e47616-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Concerns have been raised as to the safety of bisphosphonates; in particular a possible link between bisphosphonate use and upper gastrointestinal (GI) cancer. Two published studies using different study populations but drawn from earlier versions of the same national UK database, reached differing conclusions: one finding no evidence for an increase in the risk of gastric or oesophageal cancer in bisphosphonate users and one finding a small but significantly increased risk of oesophageal cancer linked to duration of bisphosphonate use.
Design-A case control study comparing bisphosphonate prescribing in cases of upper GI cancer from 1995 to 2007 using UK primary care electronic health records (GPRD). Main Outcome Measure-Relative Risk (approximated to Odds Ratio for rare events) for oesophageal and gastric cancer development in bisphosphonate users compared to non-users. The odds of being a case of oesophageal cancer, adjusted for smoking status, were significantly increased in women who had had one or more bisphosphonate prescriptions, odds ratio 1.54 (95% CI 1.27-1.88) compared to non-users. There was no significant effect on gastric cancer in women, odds ratio adjusted for smoking status, 1.06 (95% CI 0.83-1.37) and also no apparent risk in men for either oesophageal or gastric cancer, odds ratio adjusted for smoking status 0.78 (95%CI 0.56-1.09) and 0.87 (95% CI 0.55-1.36) respectively.
Our results support a small but significant increased risk of oesophageal cancer in women prescribed bisphosphonates and is based on the largest number of exposed cases to date in the UK.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23112825</pmid><doi>10.1371/journal.pone.0047616</doi><tpages>e47616</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2012-10, Vol.7 (10), p.e47616 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1970314219 |
| source | PubMed (Medline); Publicly Available Content (ProQuest) |
| subjects | Aged Alcohol use Alendronate - adverse effects Bisphosphonates Bone Density Conservation Agents - adverse effects Cancer Cancer research Case-Control Studies Confidence intervals Databases, Factual Development and progression Diphosphonates - adverse effects Electronic health records Electronic medical records Esophageal cancer Esophageal Neoplasms - chemically induced Esophagus Esophagus - drug effects Family medicine Female Gastric cancer Gastrointestinal cancer Gastrointestinal Neoplasms - chemically induced Health care Health risk assessment Health risks Health sciences Hormone replacement therapy Humans Intestines - drug effects Male Medical diagnosis Medicine Middle Aged Osteoporosis Phosphonates Population studies Practice research Primary care Public health Risk Risk Factors Smoking Stomach - drug effects Stomach cancer Studies Systematic review |
| title | Bisphosphonates and risk of upper gastrointestinal cancer--a case control study using the General Practice Research Database (GPRD) |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T20%3A03%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Bisphosphonates%20and%20risk%20of%20upper%20gastrointestinal%20cancer--a%20case%20control%20study%20using%20the%20General%20Practice%20Research%20Database%20(GPRD)&rft.jtitle=PloS%20one&rft.au=Wright,%20Ellen&rft.date=2012-10-24&rft.volume=7&rft.issue=10&rft.spage=e47616&rft.pages=e47616-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0047616&rft_dat=%3Cgale_plos_%3EA477045714%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c692t-8ed4c18becaed496c2f1787916e6b5cd467a156161c53774e526480298e416db3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1970314219&rft_id=info:pmid/23112825&rft_galeid=A477045714&rfr_iscdi=true |