Sex-differences of face coding: evidence from larger right hemispheric M170 in men and dipole source modelling

• Published in: PloS one 2013-07, Vol.8 (7), p.e69107-e69107
• Main Authors: Tiedt, Hannes O, Weber, Joachim E, Pauls, Alfred, Beier, Klaus M, Lueschow, Andreas
• Format: Article
• Language: English
• Subjects: Adult; Asymmetry; Biology; Brain Mapping; Coding; Cortex; Dipoles; Dominance; Emotions; Event-related potentials; Evoked Potentials; Face; Female; Functional Laterality; Gender; Gender aspects; Gender differences; Head; Hemispheric laterality; Humans; Localization; Magnetoencephalography; Male; Medical imaging; Medical research; Men; Neurology; Pattern recognition; Perception; Photic Stimulation; Sensors; Sex; Sex Characteristics; Sex differences; Sex Factors; Social and Behavioral Sciences; Specialization; Studies; Visual Perception - physiology; Young Adult
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0069107

The processing of faces relies on a specialized neural system comprising bilateral cortical structures with a dominance of the right hemisphere. However, due to inconsistencies of earlier findings as well as more recent results such functional lateralization has become a topic of discussion. In particular, studies employing behavioural tasks and electrophysiological methods indicate a dominance of the right hemisphere during face perception only in men whereas women exhibit symmetric and bilateral face processing. The aim of this study was to further investigate such sex differences in hemispheric processing of personally familiar and opposite-sex faces using whole-head magnetoencephalography (MEG). We found a right-lateralized M170-component in occipito-temporal sensor clusters in men as opposed to a bilateral response in women. Furthermore, the same pattern was obtained in performing dipole localization and determining dipole strength in the M170-timewindow. These results suggest asymmetric involvement of face-responsive neural structures in men and allow to ascribe this asymmetry to the fusiform gyrus. This specifies findings from previous investigations employing event-related potentials (ERP) and LORETA reconstruction methods yielding rather extended bilateral activations showing left asymmetry in women and right lateralization in men. We discuss our finding of an asymmetric fusiform activation pattern in men in terms of holistic face processing during face evaluation and sex differences with regard to visual strategies in general and interest for opposite faces in special. Taken together the pattern of hemispheric specialization observed here yields new insights into sex differences in face perception and entails further questions about interactions between biological sex, psychological gender and influences that might be stimulus-driven or task dependent.