Prognostic value of Ezrin in solid tumors: a meta-analysis of the literature

Ezrin is a cytoskeletal protein involved in tumor growth and invasion. However its prognostic value for survival in patients with solid tumor remains controversial. Several databases were searched, including Pubmed, Embase and Cochrane databases. The endpoints were overall survival (OS), progression...

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Bibliographic Details
Published in:PloS one 2013-07, Vol.8 (7), p.e68527-e68527
Main Authors: Han, Kun, Qi, WeiXiang, Gan, ZhiHua, Shen, Zan, Yao, Yang, Min, DaLiu
Format: Article
Language:English
Subjects:
Analysis
Biology
Clinical trials
Confidence intervals
Cytoskeletal Proteins - metabolism
Cytoskeleton
Data bases
Development and progression
Ezrin
Gastric cancer
Gastrointestinal cancer
Health hazards
Hospitals
Humans
Liver cancer
Medical prognosis
Medical research
Medicine
Meta-analysis
Metastasis
Neoplasms - metabolism
Neoplasms - mortality
Oncology
Patients
Prognosis
Proportional Hazards Models
Publication Bias
Radiation therapy
Signal transduction
Solid tumors
Stomach cancer
Studies
Survival
Throat cancer
Tumors
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Summary:Ezrin is a cytoskeletal protein involved in tumor growth and invasion. However its prognostic value for survival in patients with solid tumor remains controversial. Several databases were searched, including Pubmed, Embase and Cochrane databases. The endpoints were overall survival (OS), progression-free survival (PFS). The pooled hazard ratio (HR) or odds ratio (OR), and 95% confidence intervals (CI) were calculated employing fixed- or random-effects models depending on the heterogeneity of the included trials. Twenty-seven eligible trials involving 4693 patients were ultimately identified. A summary hazard ratio (HR) of all studies and sub-group hazard ratios were calculated. The combined HR suggested that a positive Ezrin expression had an impact on overall survival (OS) [1.95, 95% confidence interval (CI) 1.60-2.39; P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0068527