Activation of Wnt/β-catenin pathway in monocytes derived from chronic kidney disease patients

Patients with chronic kidney disease (CKD) have significantly increased morbidity and mortality resulting from infections and cardiovascular diseases. Since monocytes play an essential role in host immunity, this study was directed to explore the gene expression profile in order to identify differen...

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Bibliographic Details
Published in:PloS one 2013-07, Vol.8 (7), p.e68937-e68937
Main Authors: Al-Chaqmaqchi, Heevy Abdulkareem Musa, Moshfegh, Ali, Dadfar, Elham, Paulsson, Josefin, Hassan, Moustapha, Jacobson, Stefan H, Lundahl, Joachim
Format: Article
Language:English
Subjects:
Aged
Arteriosclerosis
Atherosclerosis
Biology
Blotting, Western
Cancer
Cardiovascular diseases
Case-Control Studies
Cell activation
Cell Lineage - genetics
Complications
Dendritic cells
Densitometry
DNA microarrays
Gene expression
Gene Expression Profiling
Heart diseases
Hospitals
Humans
Immunity
Immunology
Infections
Inflammation
Inflammatory response
Kidney diseases
Kidney transplantation
Medicine
Middle Aged
Monocytes
Monocytes - metabolism
Morbidity
Pathways
Patients
Peripheral blood
Renal Insufficiency, Chronic - genetics
Renal Insufficiency, Chronic - pathology
Rheumatoid arthritis
RNA - isolation & purification
Signal transduction
Signaling
Software
Stem cells
Tissue Donors
Up-Regulation - genetics
Wnt protein
Wnt Signaling Pathway - genetics
β-Catenin
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Description
Summary:Patients with chronic kidney disease (CKD) have significantly increased morbidity and mortality resulting from infections and cardiovascular diseases. Since monocytes play an essential role in host immunity, this study was directed to explore the gene expression profile in order to identify differences in activated pathways in monocytes relevant to the pathophysiology of atherosclerosis and increased susceptibility to infections. Monocytes from CKD patients (stages 4 and 5, estimated GFR
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0068937