Time-course changes of oxidative stress response to high-intensity discontinuous training versus moderate-intensity continuous training in masters runners

Beneficial systemic effects of regular physical exercise have been demonstrated to reduce risks of a number of age-related disorders. Antioxidant capacity adaptations are amongst these fundamental changes in response to exercise training. However, it has been claimed that acute physical exercise per...

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Bibliographic Details
Published in:PloS one 2014-01, Vol.9 (1), p.e87506
Main Authors: Vezzoli, Alessandra, Pugliese, Lorenzo, Marzorati, Mauro, Serpiello, Fabio Rubens, La Torre, Antonio, Porcelli, Simone
Format: Article
Language:English
Subjects:
Adaptation
Adaptations
Adolescent
Adult
Aerobics
Age
Antioxidants
Antioxidants (Nutrients)
Bioindicators
Biology
Biomarkers
Biomarkers - blood
Carbonyl compounds
Carbonyls
Chemistry
Deoxyribonucleic acid
DNA
Enzymes
Exercise - physiology
Exercise intensity
Fitness training programs
Free radicals
Gas exchange
Gene expression
Guanosine
Homeostasis
Homeostasis - physiology
Humans
Lipid peroxidation
Lipid Peroxidation - physiology
Male
Medicine
Mens health
Musculoskeletal system
Oxidation
Oxidative stress
Oxidative Stress - physiology
Oxygen
Oxygen consumption
Oxygen uptake
Peroxidation
Physical exercise
Physical fitness
Physical training
Physiology
Plasma levels
Reactive oxygen species
Reactive Oxygen Species - blood
Redox potential
Risk reduction
Rodents
Runners (Sports)
Running
Running - physiology
Thiobarbituric acid
Training
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Summary:Beneficial systemic effects of regular physical exercise have been demonstrated to reduce risks of a number of age-related disorders. Antioxidant capacity adaptations are amongst these fundamental changes in response to exercise training. However, it has been claimed that acute physical exercise performed at high intensity (>60% of maximal oxygen uptake) may result in oxidative stress, due to reactive oxygen species being generated excessively by enhanced oxygen consumption. The aim of this study was to evaluate the effect of high-intensity discontinuous training (HIDT), characterized by repeated variations of intensity and changes of redox potential, on oxidative damage. Twenty long-distance masters runners (age 47.8 ± 7.8 yr) on the basis of the individual values of gas exchange threshold were assigned to a different 8-weeks training program: continuous moderate-intensity training (MOD, n = 10) or HIDT (n = 10). In both groups before (PRE) and after (POST) training we examined the following oxidative damage markers: thiobarbituric acid reactive substances (TBARS) as marker of lipid peroxidation; protein carbonyls (PC) as marker of protein oxidation; 8-hydroxy-2-deoxy-guanosine (8-OH-dG) as a biomarker of DNA base modifications; and total antioxidant capacity (TAC) as indicator of the overall antioxidant system. Training induced a significant (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0087506