An approach for identifying brainstem dopaminergic pathways using resting state functional MRI

Here, we present an approach for identifying brainstem dopaminergic pathways using resting state functional MRI. In a group of healthy individuals, we searched for significant functional connectivity between dopamine-rich midbrain areas (substantia nigra; ventral tegmental area) and a striatal regio...

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Bibliographic Details
Published in:PloS one 2014-01, Vol.9 (1), p.e87109-e87109
Main Authors: Vytlacil, Jason, Kayser, Andrew, Miyakawa, Asako, D'Esposito, Mark
Format: Article
Language:English
Subjects:
Adolescent
Automation
Biology
Brain
Brain mapping
Brain stem
Brain Stem - metabolism
Brain Stem - physiology
Bromocriptine
Bromocriptine - pharmacology
Caudate Nucleus - metabolism
Caudate Nucleus - physiology
Cognition - physiology
Cognitive ability
Corpus Striatum - metabolism
Corpus Striatum - physiology
Dopamine
Dopamine - metabolism
Dopamine Agonists - pharmacology
Dopamine receptors
Dopaminergic Neurons - drug effects
Dopaminergic Neurons - physiology
Double-Blind Method
Female
Functional magnetic resonance imaging
Human subjects
Humans
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Memory
Mental disorders
Mesencephalon
Mesencephalon - metabolism
Mesencephalon - physiology
Neostriatum
Nerve Net - metabolism
Nerve Net - physiology
Neural networks
Neural Pathways - drug effects
Neural Pathways - physiology
Neuromodulation
Neurosciences
Pharmacology
Physiology
Psychomotor Performance - physiology
Rest - physiology
Short term memory
Substantia nigra
Substantia Nigra - metabolism
Substantia Nigra - physiology
Time series
Ventral Tegmental Area - metabolism
Ventral Tegmental Area - physiology
Ventral tegmentum
Young Adult
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Description
Summary:Here, we present an approach for identifying brainstem dopaminergic pathways using resting state functional MRI. In a group of healthy individuals, we searched for significant functional connectivity between dopamine-rich midbrain areas (substantia nigra; ventral tegmental area) and a striatal region (caudate) that was modulated by both a pharmacological challenge (the administration of the dopaminergic agonist bromocriptine) and a dopamine-sensitive cognitive trait (an individual's working memory capacity). A significant inverted-U shaped connectivity pattern was found in a subset of midbrain-striatal connections, demonstrating that resting state fMRI data is sufficiently powerful to identify brainstem neuromodulatory brain networks.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0087109