Traditional but not HIV-related factors are associated with nonalcoholic fatty liver disease in Asian patients with HIV-1 infection

The prevalence and factors associated with nonalcoholic fatty liver disease (NAFLD) are largely unknown in HIV-1 monoinfected patients. The present study elucidated the prevalence and factors associated with NAFLD among Asian patients with HIV-1 infection who underwent abdominal ultrasonography betw...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2014-01, Vol.9 (1), p.e87596-e87596
Main Authors: Nishijima, Takeshi, Gatanaga, Hiroyuki, Shimbo, Takuro, Komatsu, Hirokazu, Nozaki, Yuichi, Nagata, Naoyoshi, Kikuchi, Yoshimi, Yanase, Mikio, Oka, Shinichi
Format: Article
Language:English
Subjects:
Abdomen
Acquired immune deficiency syndrome
Adult
AIDS
Alcohol
Alcoholic beverages
Analysis
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
Asian Continental Ancestry Group
Blood pressure
Body mass
Cholesterol
Chronic infection
Collaboration
Cross-Sectional Studies
Diabetes
Didanosine
Drug therapy
Dyslipidemia
Fatty liver
Fatty Liver - complications
Fatty Liver - epidemiology
Female
Gastroenterology
Glucose
Health aspects
Hemophilia
Hepatitis
Hepatitis B
Hepatology
Highly active antiretroviral therapy
HIV
HIV Infections - complications
HIV Infections - epidemiology
HIV patients
Hospitals
Human immunodeficiency virus
Humans
Incidence
Infections
Japan - epidemiology
Kidneys
Liver
Liver diseases
Male
Medical records
Medical research
Medicine
Metabolic disorders
Metabolism
Middle Aged
Mortality
Multivariate analysis
Non-alcoholic Fatty Liver Disease
Obesity
Patients
Regression analysis
Stavudine
Studies
Substance abuse treatment
Type 2 diabetes
Ultrasonic imaging
Ultrasound
Ultrasound imaging
Viruses
Zalcitabine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The prevalence and factors associated with nonalcoholic fatty liver disease (NAFLD) are largely unknown in HIV-1 monoinfected patients. The present study elucidated the prevalence and factors associated with NAFLD among Asian patients with HIV-1 infection who underwent abdominal ultrasonography between January 2004 and March 2013. Diagnosis of NAFLD was based on the liver to kidney contrast and diffusion in hepatic echogenicity. Uni- and multi-variate logistic regression analyses were applied to estimate factors associated with NAFLD. 435 Asian patients free of chronic hepatitis B or C virus infection and without excessive alcohol intake were analyzed. NAFLD was diagnosed in 135 (31%) patients. Obesity (BMI >30 kg/m(2)) was evident in 18 (4.1%) patients, and BMI was >25 kg/m(2) in 103 (24%). Multivariate analysis identified higher BMI (per 1 kg/m(2) increment, adjusted OR = 1.198; 95% CI, 1.112-1.290; p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0087596