Sociodemographic trends in the incidence of pancreatic and biliary tract cancer in UK primary care

The UK incidence of pancreatic ductal adenocarcinoma (PDAC) is approximately 9/100,000 population compared with 1-2/100,000 for biliary tract cancer (BTC). This study explores the incidence of these cancers over time and the influence of socio-demographic and geographic factors in a UK primary care...

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Bibliographic Details
Published in:PloS one 2014-09, Vol.9 (9), p.e108498
Main Authors: Keane, Margaret G, Horsfall, Laura J, Rait, Greta, Pereira, Stephen P
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma - economics
Adenocarcinoma - epidemiology
Adult
Age Factors
Aged
Aged, 80 and over
Biliary tract
Biliary Tract Neoplasms - economics
Biliary Tract Neoplasms - epidemiology
Biology and Life Sciences
Cancer
Cholangiocarcinoma
Databases, Factual
Demographics
Deprivation
Diabetes
Disease
Epidemiology
Female
Geography
Health care
Health risk assessment
Health risks
Humans
Incidence
Male
Mathematical analysis
Medical diagnosis
Medical records
Medicine and Health Sciences
Mens health
Middle Aged
Mortality
Obesity
Pancreas
Pancreatic cancer
Pancreatic Neoplasms - economics
Pancreatic Neoplasms - epidemiology
Patients
Primary care
Primary Health Care - statistics & numerical data
Risk analysis
Risk Factors
Sex Factors
Smoking
Social Class
Sociodemographics
Trends
Tumors
United Kingdom - epidemiology
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Summary:The UK incidence of pancreatic ductal adenocarcinoma (PDAC) is approximately 9/100,000 population compared with 1-2/100,000 for biliary tract cancer (BTC). This study explores the incidence of these cancers over time and the influence of socio-demographic and geographic factors in a UK primary care cohort. This study uses data from a large UK primary care database, The Health Improvement Network (THIN). All adult patients contributing data to THIN between January 2000 and December 2010 were included. Annual incidence rates were calculated, adjusted for age, gender, time period, deprivation score (Townsend quintile) and strategic health authority. From 2000-2010, the annual incidence of PDAC increased by an average of 3% per year (95% CI 1.00-4.00%) and BTC by 4% (95% CI 2.00-6.00%). Incidence of both cancers increased steeply with age and was higher in men. BTC was associated with increasing deprivation (most deprived versus least deprived quintile (OR: 1.45 [95% CI: 1.17, 1.79.]). The overall incidence of both cancers is low but increasing. Variations in incidence may reflect changes in coding practice or increased exposure to associated risk factors.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0108498