Oxidative stress is associated with an increased antioxidant defense in elderly subjects: a multilevel approach

• Published in: PloS one 2014-09, Vol.9 (9), p.e105881
• Main Authors: Flores-Mateo, Gemma, Elosua, Roberto, Rodriguez-Blanco, Teresa, Basora-Gallisà, Josep, Bulló, Mònica, Salas-Salvadó, Jordi, Martínez-González, Miguel Ángel, Estruch, Ramon, Corella, Dolores, Fitó, Montserrat, Fiol, Miquel, Arós, Fernando, Gómez-Gracia, Enrique, Subirana, Isaac, Lapetra, José, Ruiz-Gutiérrez, Valentina, Sáez, Guillermo T, Covas, Maria-Isabel
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Aging; Antioxidants; Antioxidants - metabolism; Atherosclerosis; Biology and Life Sciences; Blood pressure; Cardiovascular disease; Cardiovascular diseases; Cholesterol; Cross-Sectional Studies; Defensive behavior; Envelliment; Enzymes; Epidemiology; Estrès oxidatiu; Female; Free radicals; Geriatrics; Glucose; Glutathione; Glutathione peroxidase; Glutathione Peroxidase - blood; Health care; Health risks; Heart; Hospitals; Humans; Hyperglycemia; Lipoproteins; Low density lipoprotein; Male; Mammals; Medicina preventiva; Medicine and Health Sciences; Middle Aged; Multilevel; Multivariate Analysis; Nutrition research; Older people; Oxidative Stress; Peroxidase; Population (statistical); Preventive medicine; Primary care; Public health; Questionnaires; Regression Analysis; Research and Analysis Methods; Risk analysis; Risk factors; Selenium; Studies; Womens health
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0105881

Studies of associations between plasma GSH-Px activity and cardiovascular risk factors have been done in humans, and contradictory results have been reported. The aim of our study was to assess the association between the scavenger antioxidant enzyme glutathione peroxidase (GSH-Px) activity in plasma and the presence of novel and classical cardiovascular risk factors in elderly patients. We performed a cross-sectional study with baseline data from a subsample of the PREDIMED (PREvención con DIeta MEDiterránea) study in Spain. Participants were 1,060 asymptomatic subjects at high risk for cardiovascular disease (CVD), aged 55 to 80, selected from 8 primary health care centers (PHCCs). We assessed classical CVD risk factors, plasma oxidized low-density lipoproteins (ox-LDL), and glutathione peroxidase (GSH-Px) using multilevel statistical procedures. Mean GSH-Px value was 612 U/L (SE: 12 U/L), with variation between PHCCs ranging from 549 to 674 U/L (Variance =  013.5; P