Combination HIV prevention among MSM in South Africa: results from agent-based modeling

HIV prevention trials have demonstrated the effectiveness of a number of behavioral and biomedical interventions. HIV prevention packages are combinations of interventions and offer potential to significantly increase the effectiveness of any single intervention. Estimates of the effectiveness of pr...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2014-11, Vol.9 (11), p.e112668-e112668
Main Authors: Brookmeyer, Ron, Boren, David, Baral, Stefan D, Bekker, Linda-Gail, Phaswana-Mafuya, Nancy, Beyrer, Chris, Sullivan, Patrick S
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Agent-based models
AIDS
Analysis
Anti-HIV Agents - therapeutic use
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
CD4 antigen
Combined Modality Therapy - methods
Computer simulation
Confidence intervals
Disease prevention
Disease transmission
Drug therapy
Epidemics
Epidemiology
Generalized linear models
Genetic Testing - methods
HIV
HIV Infections - prevention & control
HIV tests
Homosexuality, Male
Human immunodeficiency virus
Human rights
Humans
Infections
Intervention
Male
Medicine and Health Sciences
Mens health
Models, Biological
Packages
Pre-Exposure Prophylaxis - methods
Prevention
Public health
Reduction
Research and Analysis Methods
Risk taking
Safe Sex - psychology
Sexually transmitted disease prevention
Sexually transmitted diseases
Social sciences
South Africa
STD
Systematic review
Variables
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:HIV prevention trials have demonstrated the effectiveness of a number of behavioral and biomedical interventions. HIV prevention packages are combinations of interventions and offer potential to significantly increase the effectiveness of any single intervention. Estimates of the effectiveness of prevention packages are important for guiding the development of prevention strategies and for characterizing effect sizes before embarking on large scale trials. Unfortunately, most research to date has focused on testing single interventions rather than HIV prevention packages. Here we report the results from agent-based modeling of the effectiveness of HIV prevention packages for men who have sex with men (MSM) in South Africa. We consider packages consisting of four components: antiretroviral therapy for HIV infected persons with CD4 count
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0112668