Clinical predictors of outcome in patients with inflammatory dilated cardiomyopathy

The study objectives were to identify predictors of outcome in patients with inflammatory dilated cardiomyopathy (DCMi). From 2004 to 2008, 55 patients with biopsy-proven DCMi were identified and followed up for 58.2±19.8 months. Predictors of outcome were identified in a multivariable analysis with...

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Bibliographic Details
Published in:PloS one 2017-12, Vol.12 (12), p.e0188491-e0188491
Main Authors: Karatolios, Konstantinos, Holzendorf, Volker, Hatzis, George, Tousoulis, Dimitrios, Richter, Anette, Schieffer, Bernhard, Pankuweit, Sabine
Format: Article
Language:English
Subjects:
Adult
Biology and Life Sciences
Biopsy
Cardiac arrhythmia
Cardiology
Cardiomyopathy
Cardiomyopathy, Dilated - mortality
Cardiomyopathy, Dilated - pathology
Cardiomyopathy, Dilated - physiopathology
Cardiomyopathy, Dilated - therapy
Cardiovascular disease
Care and treatment
Classification
Congestive cardiomyopathy
Coronary vessels
Digitalis
Dilated cardiomyopathy
Electrocardiography
Female
Fibrillation
Genomes
Glomerular Filtration Rate
Hazard identification
Heart
Heart diseases
Heart failure
Heart Transplantation
Hospitalization
Humans
Identification methods
Inflammation
Inflammation - pathology
Inflammation - therapy
Intensive care
Male
Medical diagnosis
Medicine and Health Sciences
Middle Aged
Mortality
Outcome Assessment (Health Care)
Patient outcomes
Patients
Physiological aspects
Studies
Systematic review
Transplantation
Treatment outcome
Ventricle
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Summary:The study objectives were to identify predictors of outcome in patients with inflammatory dilated cardiomyopathy (DCMi). From 2004 to 2008, 55 patients with biopsy-proven DCMi were identified and followed up for 58.2±19.8 months. Predictors of outcome were identified in a multivariable analysis with a Cox proportional hazards analysis. The primary endpoint was a composite of death, heart transplantation and hospitalization for heart failure or ventricular arrhythmias. For the primary endpoint, a QTc interval >440msec (HR 2.84; 95% CI 1.03-7.87; p = 0.044), a glomerular filtration rate (GFR)
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0188491