Differential adipose tissue gene expression profiles in abacavir treated patients that may contribute to the understanding of cardiovascular risk: a microarray study

To compare changes in gene expression by microarray from subcutaneous adipose tissue from HIV treatment naïve patients treated with efavirenz based regimens containing abacavir (ABC), tenofovir (TDF) or zidovidine (AZT). Subcutaneous fat biopsies were obtained before, at 6- and 18-24-months after tr...

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Bibliographic Details
Published in:PloS one 2015-01, Vol.10 (1), p.e0117164
Main Authors: Shahmanesh, Mohsen, Phillips, Kenneth, Boothby, Meg, Tomlinson, Jeremy W
Format: Article
Language:English
Subjects:
Abacavir
Acquired immune deficiency syndrome
Adhesion
Adipose tissue
AIDS
AIDS treatment
Anti-HIV Agents - adverse effects
Anti-HIV Agents - therapeutic use
Antiretroviral agents
Antiretroviral drugs
Body fat
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - chemically induced
Care and treatment
CD4 antigen
Cell adhesion
Data processing
Dideoxynucleosides - adverse effects
Dideoxynucleosides - therapeutic use
Divergence
DNA microarrays
Efavirenz
Enrichment
Environmental information
Extracellular matrix
Gene expression
Gene set enrichment analysis
Genes
Genomes
Genomics
Health risks
HIV
HIV Infections - drug therapy
Human immunodeficiency virus
Humans
Information processing
Leukocyte migration
Leukocytes
Lipids
Medical research
Minority & ethnic groups
Oligonucleotide Array Sequence Analysis
Patients
Risk
Risk factors
Subcutaneous Fat - drug effects
Subcutaneous Fat - metabolism
Subcutaneous Fat - pathology
Tenofovir
Time Factors
Tissues
Transcriptome - drug effects
Zidovudine
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Summary:To compare changes in gene expression by microarray from subcutaneous adipose tissue from HIV treatment naïve patients treated with efavirenz based regimens containing abacavir (ABC), tenofovir (TDF) or zidovidine (AZT). Subcutaneous fat biopsies were obtained before, at 6- and 18-24-months after treatment, and from HIV negative controls. Groups were age, ethnicity, weight, biochemical profile, and pre-treatment CD4 count matched. Microarray data was generated using the Agilent Whole Human Genome Microarray. Identification of differentially expressed genes and genomic response pathways was performed using limma and gene set enrichment analysis. There were significant divergences between ABC and the other two groups 6 months after treatment in genes controlling cell adhesion and environmental information processing, with some convergence at 18-24 months. Compared to controls the ABC group, but not AZT or TDF showed enrichment of genes controlling adherence junction, at 6 months and 18-24 months (adjusted p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0117164