Clinical features and risk factors for atazanavir (ATV)-associated urolithiasis: a case-control study

Clinical features and risk factors for atazanavir (ATV)-associated urolithiasis have not been fully investigated. We reviewed all cases of ATV-containing urolithiasis identified by infrared spectrophotometry among HIV-infected patients over a 5-year period to describe their clinical features and out...

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Bibliographic Details
Published in:PloS one 2014-11, Vol.9 (11), p.e112836-e112836
Main Authors: Lafaurie, Matthieu, De Sousa, Barbara, Ponscarme, Diane, Lapidus, Nathanael, Daudon, Michel, Weiss, Laurence, Rioux, Christophe, Fourn, Erwan, Katlama, Christine, Molina, Jean-Michel
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adult
AIDS
Anti-HIV Agents - adverse effects
Anti-HIV Agents - therapeutic use
Antiretroviral drugs
Atazanavir Sulfate
Bilirubin
Case-Control Studies
Cases (containers)
CD4 antigen
Female
Hematuria
Hepatitis
Hepatitis C
HIV
HIV Infections - drug therapy
Human health and pathology
Human immunodeficiency virus
Humans
Identification methods
Indinavir
Infrared spectrophotometers
Laboratories
Life Sciences
Lithiasis
Male
Medication
Medicine and health sciences
Middle Aged
Oligopeptides - adverse effects
Oligopeptides - therapeutic use
Pain
Patients
Pharmaceutical sciences
Pyridines - adverse effects
Pyridines - therapeutic use
Regression analysis
Renal function
Ribonucleic acid
Risk analysis
Risk Factors
Ritonavir
RNA
Spectrophotometry
Surgery
Urolithiasis
Urolithiasis - chemically induced
Urology and Nephrology
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Summary:Clinical features and risk factors for atazanavir (ATV)-associated urolithiasis have not been fully investigated. We reviewed all cases of ATV-containing urolithiasis identified by infrared spectrophotometry among HIV-infected patients over a 5-year period to describe their clinical features and outcome. A case-control study was performed to identify risk factors associated with ATV-associated urolithiasis using univariate and multivariate logistic regression analyses. 30 cases of ATV-associated urolithiasis were analyzed. Patients were mostly men (87%), median age: 45.5 years, median CD4 cell count: 443 cells/µL and 97% had plasma HIV RNA level
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0112836