Effectiveness of atrial fibrillation rotor ablation is dependent on conduction velocity: An in-silico 3-dimensional modeling study

We previously reported that stable rotors are observed in in-silico human atrial fibrillation (AF) models, and are well represented by a dominant frequency (DF). In the current study, we hypothesized that the outcome of DF ablation is affected by conduction velocity (CV) conditions and examined this...

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Bibliographic Details
Published in:PloS one 2017-12, Vol.12 (12), p.e0190398-e0190398
Main Authors: Lim, Byounghyun, Hwang, Minki, Song, Jun-Seop, Ryu, Ah-Jin, Joung, Boyoung, Shim, Eun Bo, Ryu, Hyungon, Pak, Hui-Nam
Format: Article
Language:English
Subjects:
Ablation
Aged
Algorithms
Anisotropy
Atrial fibrillation
Atrial Fibrillation - surgery
Atrium
Audio frequencies
Biology and Life Sciences
Biomedical engineering
Cardiac arrhythmia
Care and treatment
Catheter Ablation - instrumentation
Catheter Ablation - methods
Catheters
Computed tomography
Computer Simulation
Conduction
Defibrillators
Dimensional stability
Engineering and Technology
Female
Fibrillation
Humans
Maintenance
Male
Medicine and Health Sciences
Middle Aged
Modelling
Physical Sciences
Rotors
Software
Testing
Three dimensional models
Velocity
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Summary:We previously reported that stable rotors are observed in in-silico human atrial fibrillation (AF) models, and are well represented by a dominant frequency (DF). In the current study, we hypothesized that the outcome of DF ablation is affected by conduction velocity (CV) conditions and examined this hypothesis using in-silico 3D-AF modeling. We integrated 3D CT images of left atrium obtained from 10 patients with persistent AF (80% male, 61.8±13.5 years old) into in-silico AF model. We compared AF maintenance durations (max 300s), spatiotemporal stabilities of DF, phase singularity (PS) number, life-span of PS, and AF termination or defragmentation rates after virtual DF ablation with 5 different CV conditions (0.2, 0.3, 0.4, 0.5, and 0.6m/s). 1. AF maintenance duration (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0190398