Cognitive performance and cerebrospinal fluid biomarkers of neurodegeneration: a study of patients with bipolar disorder and healthy controls

The purpose of the present study was to investigate if cerebrospinal fluid (CSF) biomarkers of neurodegeneration are associated with cognition in bipolar disorder and healthy controls, respectively. CSF concentrations of total and phosphorylated tau, amyloid beta (Aβ)1-42, ratios of Aβ42/40 and Aβ42...

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Bibliographic Details
Published in:PloS one 2015-05, Vol.10 (5), p.e0127100-e0127100
Main Authors: Rolstad, Sindre, Jakobsson, Joel, Sellgren, Carl, Ekman, Carl-Johan, Blennow, Kaj, Zetterberg, Henrik, Pålsson, Erik, Landén, Mikael
Format: Article
Language:English
Subjects:
1ST-DEGREE RELATIVES
A-BETA
Adult
Alzheimer's disease
ALZHEIMER-DISEASE
Alzheimers disease
Amyloid beta-Peptides - cerebrospinal fluid
AMYLOID PRECURSOR PROTEIN
Analysis
Biological markers
Biomarkers
Biomarkers - cerebrospinal fluid
Bipolar disorder
Bipolar Disorder - cerebrospinal fluid
Bipolar Disorder - metabolism
Bipolar Disorder - psychology
Brain
Care and treatment
Case-Control Studies
Cerebrospinal fluid
Cognition
Cognition Disorders - cerebrospinal fluid
Cognition Disorders - metabolism
Cognition Disorders - psychology
Cognitive ability
Complications and side effects
Depression (Mood disorder)
Drugs
Epidemiology
Family medical history
Female
Humans
IMPACT
IMPAIRMENT
IN-VIVO
Male
Medical research
Medicin och hälsovetenskap
Memory
METAANALYSIS
Middle Aged
Multidisciplinary Sciences
Neurodegeneration
Neurology
Neuropsychological Tests
Neurosciences
NEUROTOXICITY
Neurovetenskaper
NMR
Nuclear magnetic resonance
Patients
Physiology
Proteins
Regression analysis
Regression models
Risk factors
SCHIZOPHRENIA
Studies
Tau protein
tau Proteins - cerebrospinal fluid
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Description
Summary:The purpose of the present study was to investigate if cerebrospinal fluid (CSF) biomarkers of neurodegeneration are associated with cognition in bipolar disorder and healthy controls, respectively. CSF concentrations of total and phosphorylated tau, amyloid beta (Aβ)1-42, ratios of Aβ42/40 and Aβ42/38, soluble amyloid precursor protein α and β, and neurofilament light chain protein were analyzed in relation to neuropsychological performance in 82 euthymic bipolar disorder patients and 71 healthy controls. Linear regression models were applied to account for performance in five cognitive domains using the CSF biomarkers. In patients, the CSF biomarkers explained a significant proportion of the variance (15-36%, p=.002 -
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0127100