Prognostic value of pretreatment albumin/globulin ratio in digestive system cancers: A meta-analysis

The albumin/globulin ratio (AGR) has been widely reported to be a potential predictor of prognosis in digestive system cancers (DSCs), but convincing conclusions have not been made. Therefore, herein, we performed a meta-analysis of relevant studies regarding this topic to evaluate the prognostic va...

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Bibliographic Details
Published in:PloS one 2018-01, Vol.13 (1), p.e0189839-e0189839
Main Authors: Guo, Hui-Wen, Yuan, Tang-Zhan, Chen, Jia-Xi, Zheng, Yang
Format: Article
Language:English
Subjects:
Albumin
Albumins - metabolism
Bias
Bioindicators
Biology and Life Sciences
Biomarkers
Biomarkers, Tumor - blood
Biometrics
Cancer
Colorectal cancer
Digestive system
Digestive System Neoplasms - blood
Digestive System Neoplasms - pathology
Epidemiology
Esophagus
Gastric cancer
Globulins
Globulins - metabolism
Humans
Inflammation
Liver cancer
Medical ethics
Medical prognosis
Medicine and Health Sciences
Meta-analysis
Multivariate analysis
Pancreatic cancer
Patients
People and Places
Physical Sciences
Prognosis
Research and Analysis Methods
Science Policy
Stomach cancer
Studies
Surgery
Survival
Survival Rate
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Summary:The albumin/globulin ratio (AGR) has been widely reported to be a potential predictor of prognosis in digestive system cancers (DSCs), but convincing conclusions have not been made. Therefore, herein, we performed a meta-analysis of relevant studies regarding this topic to evaluate the prognostic value of AGR in patients with DSCs. Three databases, including PubMed, EMBase, and Web of science, were searched comprehensively for eligible studies through September 8, 2017. The outcomes of interest included overall survival (OS), disease-free survival (DFS), and cancer-specific survival (CSS). In our meta-analysis, pooled analysis of 13 studies with 9269 patients showed that a low AGR was significantly correlated with poor OS (HR = 1.94; 95% CI: 1.57-2.38; P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0189839