Epidemiology of Australian Influenza-Related Paediatric Intensive Care Unit Admissions, 1997-2013

Influenza virus predictably causes an annual epidemic resulting in a considerable burden of illness in Australia. Children are disproportionately affected and can experience severe illness and complications, which occasionally result in death. We conducted a retrospective descriptive study using dat...

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Published in:PloS one 2016-03, Vol.11 (3), p.e0152305-e0152305
Main Authors: Kaczmarek, Marlena C, Ware, Robert S, Coulthard, Mark G, McEniery, Julie, Lambert, Stephen B
Format: Article
Language:English
Subjects:
Adolescent
Age
Asthma
Australia - epidemiology
Biology and Life Sciences
Bronchopneumonia
Child
Child, Preschool
Children
Children & youth
Childrens health
Codes
Comorbidity
Complications
Demographic aspects
Demography
Disease
Epidemics
Epidemiology
Female
Health surveillance
Hospitals
Humans
Illnesses
Infant
Infant, Newborn
Infections
Influenza
Influenza, Human - epidemiology
Intensive care
Intensive Care Units, Pediatric - statistics & numerical data
Lung diseases
Male
Medical diagnosis
Medical research
Medicine
Medicine and Health Sciences
Morbidity
Patient Admission - statistics & numerical data
People and Places
Pneumonitis
Public health
Respiratory syncytial virus
Risk factors
Seasons
Surveillance
Vaccines
Viruses
Womens health
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Ware, Robert S
Coulthard, Mark G
McEniery, Julie
Lambert, Stephen B
description Influenza virus predictably causes an annual epidemic resulting in a considerable burden of illness in Australia. Children are disproportionately affected and can experience severe illness and complications, which occasionally result in death. We conducted a retrospective descriptive study using data collated in the Australian and New Zealand Paediatric Intensive Care (ANZPIC) Registry of influenza-related intensive care unit (ICU) admissions over a 17-year period (1997-2013, inclusive) in children
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Children are disproportionately affected and can experience severe illness and complications, which occasionally result in death. We conducted a retrospective descriptive study using data collated in the Australian and New Zealand Paediatric Intensive Care (ANZPIC) Registry of influenza-related intensive care unit (ICU) admissions over a 17-year period (1997-2013, inclusive) in children &lt;16 years old. National laboratory-confirmed influenza notifications were used for comparison. Between 1997 and 2013, a total of 704 influenza-related ICU admissions were recorded, at a rate of 6.2 per 1,000 all-cause ICU admissions. Age at admission ranged from 0 days and 15.9 years (median = 2.1 years), with 135 (19.2%) aged &lt;6 months. Pneumonia/pneumonitis and bronchiolitis were the most common primary diagnoses among influenza-related admissions (21.9% and 13.6%, respectively). More than half of total cases (59.2%) were previously healthy (no co-morbidities recorded), and in the remainder, chronic lung disease (16.7%) and asthma (12.5%) were the most common co-morbidities recorded. Pathogen co-detection occurred in 24.7% of cases, most commonly with respiratory syncytial virus or a staphylococcal species. Median length of all ICU admissions was 3.2 days (range 2.0 hours- 107.4 days) and 361 (51.3%) admissions required invasive respiratory support for a median duration of 4.3 days (range 0.2 hours- 107.5 days). There were 27 deaths recorded, 14 (51.9%) in children without a recorded co-morbidity. 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Children are disproportionately affected and can experience severe illness and complications, which occasionally result in death. We conducted a retrospective descriptive study using data collated in the Australian and New Zealand Paediatric Intensive Care (ANZPIC) Registry of influenza-related intensive care unit (ICU) admissions over a 17-year period (1997-2013, inclusive) in children &lt;16 years old. National laboratory-confirmed influenza notifications were used for comparison. Between 1997 and 2013, a total of 704 influenza-related ICU admissions were recorded, at a rate of 6.2 per 1,000 all-cause ICU admissions. Age at admission ranged from 0 days and 15.9 years (median = 2.1 years), with 135 (19.2%) aged &lt;6 months. Pneumonia/pneumonitis and bronchiolitis were the most common primary diagnoses among influenza-related admissions (21.9% and 13.6%, respectively). 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Children are disproportionately affected and can experience severe illness and complications, which occasionally result in death. We conducted a retrospective descriptive study using data collated in the Australian and New Zealand Paediatric Intensive Care (ANZPIC) Registry of influenza-related intensive care unit (ICU) admissions over a 17-year period (1997-2013, inclusive) in children &lt;16 years old. National laboratory-confirmed influenza notifications were used for comparison. Between 1997 and 2013, a total of 704 influenza-related ICU admissions were recorded, at a rate of 6.2 per 1,000 all-cause ICU admissions. Age at admission ranged from 0 days and 15.9 years (median = 2.1 years), with 135 (19.2%) aged &lt;6 months. Pneumonia/pneumonitis and bronchiolitis were the most common primary diagnoses among influenza-related admissions (21.9% and 13.6%, respectively). More than half of total cases (59.2%) were previously healthy (no co-morbidities recorded), and in the remainder, chronic lung disease (16.7%) and asthma (12.5%) were the most common co-morbidities recorded. Pathogen co-detection occurred in 24.7% of cases, most commonly with respiratory syncytial virus or a staphylococcal species. Median length of all ICU admissions was 3.2 days (range 2.0 hours- 107.4 days) and 361 (51.3%) admissions required invasive respiratory support for a median duration of 4.3 days (range 0.2 hours- 107.5 days). There were 27 deaths recorded, 14 (51.9%) in children without a recorded co-morbidity. Influenza causes a substantial number of ICU admissions in Australian children each year with the majority occurring in previously healthy children.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27023740</pmid><doi>10.1371/journal.pone.0152305</doi><oa>free_for_read</oa></addata></record>
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1932-6203
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source PMC (PubMed Central); Publicly Available Content (ProQuest)
subjects Adolescent
Age
Asthma
Australia - epidemiology
Biology and Life Sciences
Bronchopneumonia
Child
Child, Preschool
Children
Children & youth
Childrens health
Codes
Comorbidity
Complications
Demographic aspects
Demography
Disease
Epidemics
Epidemiology
Female
Health surveillance
Hospitals
Humans
Illnesses
Infant
Infant, Newborn
Infections
Influenza
Influenza, Human - epidemiology
Intensive care
Intensive Care Units, Pediatric - statistics & numerical data
Lung diseases
Male
Medical diagnosis
Medical research
Medicine
Medicine and Health Sciences
Morbidity
Patient Admission - statistics & numerical data
People and Places
Pneumonitis
Public health
Respiratory syncytial virus
Risk factors
Seasons
Surveillance
Vaccines
Viruses
Womens health
title Epidemiology of Australian Influenza-Related Paediatric Intensive Care Unit Admissions, 1997-2013
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