CTLs, a new class of RING-H2 ubiquitin ligases uncovered by YEELL, a motif close to the RING domain that is present across eukaryotes

RING ubiquitin E3 ligases enclose a RING domain for ubiquitin ligase activity and associated domains and/or conserved motifs outside the RING domain that collectively facilitate their classification and usually reveal some of key information related to mechanism of action. Here we describe a new fam...

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Bibliographic Details
Published in:PloS one 2018-01, Vol.13 (1), p.e0190969-e0190969
Main Authors: Jiménez-López, Domingo, Aguilar-Henonin, Laura, González-Prieto, Juan Manuel, Aguilar-Hernández, Victor, Guzmán, Plinio
Format: Article
Language:English
Subjects:
Algae
Amino Acid Motifs
Amino Acid Sequence
Amino acids
Analysis
Angiosperms
Arabidopsis thaliana
Bioinformatics
Biology and Life Sciences
Computer and Information Sciences
Conserved Sequence
Cytotoxicity
Eukaryotes
Eukaryotic Cells
Evolution
Fungi
Gene expression
Genes
Genetic aspects
Genetic polymorphisms
Genomes
Genomics
Introns
Ligands
Ligases
Lymphocytes T
Molecular biology
Phylogenetics
Phylogeny
Physiological aspects
Plant genetics
Proteins
Research and Analysis Methods
Sequence Homology, Amino Acid
Spliceosomes - genetics
T cells
Ubiquitin
Ubiquitin-protein ligase
Ubiquitin-Protein Ligases - chemistry
Ubiquitin-Protein Ligases - classification
Ubiquitin-Protein Ligases - genetics
Ubiquitin-Protein Ligases - metabolism
Vertebrates
Zinc
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Description
Summary:RING ubiquitin E3 ligases enclose a RING domain for ubiquitin ligase activity and associated domains and/or conserved motifs outside the RING domain that collectively facilitate their classification and usually reveal some of key information related to mechanism of action. Here we describe a new family of E3 ligases that encodes a RING-H2 domain related in sequence to the ATL and BTL RING-H2 domains. This family, named CTL, encodes a motif designed as YEELL that expands 21 amino acids next to the RING-H2 domain that is present across most eukaryotic lineages. E3 ubiquitin ligase BIG BROTHER is a plant CTL that regulates organ size, and SUMO-targeted ubiquitin E3 ligase RNF111/ARKADIA is a vertebrate CTL. Basal animal and vertebrate, as well as fungi species, encode a single CTL gene that constraints the number of paralogs observed in vertebrates. Conversely, as previously described in ATL and BTL families in plants, CTL genes range from a single copy in green algae and 3 to 5 copies in basal species to 9 to 35 copies in angiosperms. Our analysis describes key structural features of a novel family of E3 ubiquitin ligases as an integral component of the set of core eukaryotic genes.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0190969