Efficacy of lateral- versus medial-approach hip joint capsule denervation as surgical treatments of the hip joint pain; a neuronal tract tracing study in the sheep

• Published in: PloS one 2018-01, Vol.13 (1), p.e0190052-e0190052
• Main Authors: Sienkiewicz, Waldemar, Dudek, Agnieszka, Czaja, Krzysztof, Janeczek, Maciej, Chrószcz, Aleksander, Kaleczyc, Jerzy
• Format: Article
• Language: English
• Subjects: Animals; Arthralgia; Arthritis; Biology and Life Sciences; Body weight; Care and treatment; Denervation; Dorsal root ganglia; Fentanyl; Ganglia; Hip; Hip joint; Hip Joint - innervation; Hip Joint - physiology; Innervation; Life sciences; Male; Medicine and Health Sciences; Methods; Neuronal Tract-Tracers; Neurons; Pain; Patient outcomes; Reduction; Sacrum; Sensory neurons; Sheep; Studies; Surgery; Veterinary medicine
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0190052

To evaluate efficacy of denervation of the of the hip joint capsule (HJC), as a treatment of hip joint pain. Specifically, we tested the hypothesis that HJC denervation will significantly reduce the number of sensory neurons innervating the capsule. Denervation of the HJC from a medial or lateral approach was followed by retrograde tracing of sensory neurons innervating the capsule. Twenty adult male sheep (30-40 kg of body weight; Polish merino breed) were used in the study. The hip joint was denervated from medial (n = 5) or lateral (n = 5) surgical approaches. Immediately after denervation, the retrograde neural tract tracer Fast Blue (FB) was injected into the HJC. An additional ten animals (n = 5 for medial and n = 5 for lateral approach) received the same treatment without HJC denervation to provide the appropriate controls. Results of the study revealed that the vast majority of retrogradely labelled sensory neurons innervating the HJC originate from fifth lumbar to second sacral dorsal root ganglia. Both the medial and the lateral denervations significantly reduced the number of sensory neurons innervating the HJC (39.2% and 69.0% reduction respectively). These results show that denervation of the HJC is an effective surgical procedure for reduction of the sensory neuronal input to the HJC. Moreover, the lateral approach was found to be significantly more effective for reducing sensory innervation as compared to the medial one.