Challenges to studying the health effects of early life environmental chemical exposures on children's health

Epidemiological studies play an important role in quantifying how early life environmental chemical exposures influence the risk of childhood diseases. These studies face at least four major challenges that can produce noise when trying to identify signals of associations between chemical exposure a...

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Bibliographic Details
Published in:PLoS biology 2017-12, Vol.15 (12), p.e2002800
Main Authors: Braun, Joseph M, Gray, Kimberly
Format: Article
Language:English
Subjects:
Biology and Life Sciences
Bisphenol A
Chemicals
Child
Child Health
Child, Preschool
Children
Children & youth
Childrens health
Data collection
Disease
Diseases
Ecological risk assessment
Ecology and Environmental Sciences
Environment
Environmental aspects
Environmental effects
Environmental Exposure - adverse effects
Environmental Exposure - analysis
Environmental health
Environmental Health - methods
Environmental Pollutants - adverse effects
Epidemiology
Exposure
Hazardous substances
Health aspects
Health risks
Health sciences
Humans
Laboratory animals
Medicine and Health Sciences
Noise
PCB
Pesticides
Physical Sciences
Polychlorinated biphenyls
Research Design
Studies
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Summary:Epidemiological studies play an important role in quantifying how early life environmental chemical exposures influence the risk of childhood diseases. These studies face at least four major challenges that can produce noise when trying to identify signals of associations between chemical exposure and childhood health. Challenges include accurately estimating chemical exposure, confounding from causes of both exposure and disease, identifying periods of heightened vulnerability to chemical exposures, and determining the effects of chemical mixtures. We provide recommendations that will aid in identifying these signals with more precision.
ISSN:1545-7885
1544-9173
1545-7885
DOI:10.1371/journal.pbio.2002800