Serum apolipoprotein E may be a novel biomarker of migraine

Migraine attacks alter various molecules that might be related to the pathophysiology of migraine, such as serotonin, calcitonin gene-related peptide, and nitric oxide. The underlying pathophysiology of migraine is as yet unclear. We explored key proteins related to the pathogenesis of migraine here...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2018-01, Vol.13 (1), p.e0190620-e0190620
Main Authors: Yuasa, Naoki, Nagata, Eiichiro, Fujii, Natsuko, Ito, Masatoshi, Tsukamoto, Hideo, Takizawa, Shunya
Format: Article
Language:English
Subjects:
Apolipoprotein E
Apolipoproteins
Biology and Life Sciences
Biomarkers
Calcitonin
Calcitonin gene-related peptide
Diagnostic systems
Gel electrophoresis
Headache
Headaches
Lipoproteins
Medical research
Medicine
Medicine and Health Sciences
Migraine
Neurology
Nitric oxide
Pain
Pathogenesis
Patients
Proteins
Serotonin
Spectrometry
Statistical analysis
Statistical methods
Two dimensional analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Migraine attacks alter various molecules that might be related to the pathophysiology of migraine, such as serotonin, calcitonin gene-related peptide, and nitric oxide. The underlying pathophysiology of migraine is as yet unclear. We explored key proteins related to the pathogenesis of migraine here. Serum was collected from two patients with migraine with aura (MA) and seven patients with migraine without aura (MO) during attack-free periods and migraine attacks. Samples were analyzed using 2-dimensional gel electrophoresis. Nineteen protein spots were altered between the attack-free versus migraine attack periods. Mass spectrometric analysis was performed to identify the proteins within each of the 19 altered spots. Thirty-six proteins were significantly altered in samples collected during attack-free periods versus migraine attacks. The protein with the statistically most significant MASCOT/Mowse score (268±112) among lipoproteins was apolipoprotein (ApoE). In the MA and MO groups, ApoE protein levels were significantly higher during migraine attack than during the attack-free period (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0190620