Dynamics and complexity of body temperature in preterm infants nursed in incubators

Poor control of body temperature is associated with mortality and major morbidity in preterm infants. We aimed to quantify its dynamics and complexity to evaluate whether indices from fluctuation analyses of temperature time series obtained within the first five days of life are associated with gest...

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Bibliographic Details
Published in:PloS one 2017-04, Vol.12 (4), p.e0176670-e0176670
Main Authors: Jost, Kerstin, Pramana, Isabelle, Delgado-Eckert, Edgar, Kumar, Nitin, Datta, Alexandre N, Frey, Urs, Schulzke, Sven M
Format: Article
Language:English
Subjects:
Babies
Behavioral sciences
Biology and Life Sciences
Birth weight
Body Size
Body Temperature
Body Temperature Regulation
Coefficient of variation
Comorbidity
Complexity
Data processing
Dynamic tests
Entropy
Female
Fourier transforms
Gestational Age
Heart rate
Heat
Humans
Incubators
Incubators, Infant
Infant, Newborn
Infant, Premature - physiology
Infants
Linear Models
Male
Mathematical analysis
Medicine and Health Sciences
Metabolism
Morbidity
Mortality
Newborn babies
Pediatrics
People and Places
Physical Sciences
Physiology
Premature babies
Premature birth
Regression Analysis
Research and Analysis Methods
Respiration
Scaling
Sepsis
Skin
Temperature
Temperature effects
Temperature fluctuations
Time series
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Summary:Poor control of body temperature is associated with mortality and major morbidity in preterm infants. We aimed to quantify its dynamics and complexity to evaluate whether indices from fluctuation analyses of temperature time series obtained within the first five days of life are associated with gestational age (GA) and body size at birth, and presence and severity of typical comorbidities of preterm birth. We recorded 3h-time series of body temperature using a skin electrode in incubator-nursed preterm infants. We calculated mean and coefficient of variation of body temperature, scaling exponent alpha (Talpha) derived from detrended fluctuation analysis, and sample entropy (TSampEn) of temperature fluctuations. Data were analysed by multilevel multivariable linear regression. Data of satisfactory technical quality were obtained from 285/357 measurements (80%) in 73/90 infants (81%) with a mean (range) GA of 30.1 (24.0-34.0) weeks. We found a positive association of Talpha with increasing levels of respiratory support after adjusting for GA and birth weight z-score (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0176670