Changes in aortic pulse wave velocity of four thoracic aortic stent grafts in an ex vivo porcine model

Thoracic endovascular aortic repair (TEVAR) has been shown to lead to increased aortic stiffness. The aim of this study was to investigate the effect of stent graft type and stent graft length on aortic stiffness in a controlled, experimental setting. Twenty porcine thoracic aortas were connected to...

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Bibliographic Details
Published in:PloS one 2017-10, Vol.12 (10), p.e0186080-e0186080
Main Authors: de Beaufort, Hector W L, Coda, Margherita, Conti, Michele, van Bakel, Theodorus M J, Nauta, Foeke J H, Lanzarone, Ettore, Moll, Frans L, van Herwaarden, Joost A, Auricchio, Ferdinando, Trimarchi, Santi
Format: Article
Language:English
Subjects:
Analysis
Aneurysms
Animals
Aorta
Aorta, Thoracic - physiology
Aorta, Thoracic - surgery
Architectural engineering
Biology and Life Sciences
Cardiovascular system
Civil engineering
Control methods
Coronary vessels
Correlation analysis
Grafting
Grafts
Implants
In Vitro Techniques
Medical research
Medicine and Health Sciences
Models, Animal
Physical Sciences
Physiology
Polyesters
Pressure distribution
Regression analysis
Research and Analysis Methods
Stents
Stiffness
Surgical implants
Swine
Thorax
Vascular surgery
Velocity
Wave velocity
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Summary:Thoracic endovascular aortic repair (TEVAR) has been shown to lead to increased aortic stiffness. The aim of this study was to investigate the effect of stent graft type and stent graft length on aortic stiffness in a controlled, experimental setting. Twenty porcine thoracic aortas were connected to a pulsatile mock loop system. Intraluminal pressure was recorded at two sites in order to measure pulse wave velocity (PWV) for each aorta: before stent graft deployment (t1); after deployment of a 100-mm long stent graft (t2); and after distal extension through deployment of a second 100-mm long stent graft (t3). Four different types of stent grafts (Conformable Gore® TAG® Device, Bolton Relay® Device, Cook Zenith Alpha™, and Medtronic Valiant®) were evaluated. For the total cohort of 20 aortas, PWV increased by a mean 0.6 m/s or 8.9% of baseline PWV after deployment of a 100-mm proximal stent graft (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0186080