Insulin resistance in lean and overweight non-diabetic Caucasian adults: Study of its relationship with liver triglyceride content, waist circumference and BMI

Insulin resistance is the pathophysiological precursor of type 2 diabetes mellitus (DM-2), and its relationship with non-alcoholic fatty liver disease (NAFLD) has been widely studied in patients with obesity or metabolic syndrome using not only ultrasound but also liver biopsies or proton magnetic r...

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Bibliographic Details
Published in:PloS one 2018-02, Vol.13 (2), p.e0192663-e0192663
Main Authors: Gonzalez-Cantero, Jorge, Martin-Rodriguez, Jose Luis, Gonzalez-Cantero, Alvaro, Arrebola, Juan Pedro, Gonzalez-Calvin, Jorge Luis
Format: Article
Language:English
Subjects:
Abdomen
Adiponectin
Adipose tissue
Adult
Adults
Aged
Alcohol
Biology and Life Sciences
Biopsy
Body mass
Body Mass Index
Body weight
Cardiovascular disease
Case-Control Studies
Dermatology
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
European Continental Ancestry Group
Family medical history
Fatty liver
Female
Health risks
Hepatitis
Hospitals
Humans
Insulin
Insulin resistance
Irritable bowel syndrome
Liver
Liver - metabolism
Liver diseases
Magnetic resonance
Magnetic resonance spectroscopy
Male
Medical imaging
Medicine and Health Sciences
Metabolic disorders
Metabolic syndrome
Metabolism
Middle Aged
Non-alcoholic Fatty Liver Disease - metabolism
Obesity
Overweight
Physical Sciences
Proton magnetic resonance
Regression analysis
Research and Analysis Methods
Resistance factors
Risk analysis
Risk factors
Spectroscopy
Spectrum analysis
Studies
Tomography
Triglycerides - metabolism
Tumor necrosis factor
Tumor necrosis factor-TNF
Ultrasonic imaging
Ultrasound
Waist Circumference
White people
Whites
Women
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Summary:Insulin resistance is the pathophysiological precursor of type 2 diabetes mellitus (DM-2), and its relationship with non-alcoholic fatty liver disease (NAFLD) has been widely studied in patients with obesity or metabolic syndrome using not only ultrasound but also liver biopsies or proton magnetic resonance spectroscopy (H1-MRS) to assess liver fat content. In contrast, there are no studies on insulin resistance and NAFLD in lean or overweight Caucasian individuals using H1-MRS or liver biopsies for the quantification of hepatic triglyceride content. Our objectives were to study the presence of insulin resistance in lean and overweight Caucasian adults and investigate its possible relationship with liver triglyceride content, waist circumference (as proxy of visceral adiposity), BMI, and cardiometabolic risk factors. A cross-sectional study was conducted in 113 non-obese, non-diabetic individuals classified as overweight (BMI 25-29.9 kg/m2) or lean (BMI 19.5-24.9 kg/m2). Hepatic triglyceride content was quantified by 3T H1-MRS. NAFLD was defined as hepatic triglyceride content >5.56%. Insulin resistance (HOMA-IR), serum adiponectin, and tumor necrosis factor (TNF) were determined. HOMA-IR was significantly correlated with hepatic triglyceride content (r:0.76; p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0192663