High prevalence of S. Stercoralis infection among patients with Chagas disease: A retrospective case-control study

• Published in: PLoS neglected tropical diseases 2018-01, Vol.12 (1), p.e0006199-e0006199
• Main Authors: Puerta-Alcalde, Pedro, Gomez-Junyent, Joan, Requena-Mendez, Ana, Pinazo, Maria Jesús, Álvarez-Martínez, Miriam José, Rodríguez, Natalia, Gascon, Joaquim, Muñoz, Jose
• Format: Article
• Language: English
• Subjects: Analysis; Biology and Life Sciences; Case studies; Causes of; Chagas disease; Cohorts; Disease; Disease control; Distribution; Earth Sciences; Epidemiology; Health aspects; Hospitals; Infections; Malaltia de Chagas; Malalties parasitàries; Medical personnel; Medical research; Medicine and Health Sciences; Migrants; Multivariate analysis; Parasitic diseases; Patients; Physicians; Physiological aspects; Protozoa; Regression analysis; Regression models; Rural areas; Serology; Strongyloides; Strongyloides stercoralis; Strongyloidiasis; Strongyloididae; Tropical climate; Tropical diseases; Trypanosoma cruzi; Vector-borne diseases
• ISSN: 1935-2735; 1935-2727; 1935-2735
• DOI: 10.1371/journal.pntd.0006199

We evaluate the association between Trypanosoma cruzi infection and strongyloidiasis in a cohort of Latin American (LA) migrants screened for both infections in a non-endemic setting. Case-control study including LA individuals who were systematically screened for T. cruzi infection and strongyloidiasis between January 2013 and April 2015. Individuals were included as cases if they had a positive serological result for Strongyloides stercoralis. Controls were randomly selected from the cohort of individuals screened for T. cruzi infection that tested negative for S. stercoralis serology. The association between T. cruzi infection and strongyloidiasis was evaluated by logistic regression models. During the study period, 361 individuals were screened for both infections. 52 (14.4%) individuals had a positive serological result for strongyloidiasis (cases) and 104 participants with negative results were randomly selected as controls. 76 (48.7%) indiviuals had a positive serological result for T. cruzi. Factors associated with a positive T. cruzi serology were Bolivian origin (94.7% vs 78.7%; p = 0.003), coming from a rural area (90.8% vs 68.7%; p = 0.001), having lived in an adobe house (88.2% vs 70%; p = 0.006) and a referred contact with triatomine bugs (86.7% vs 63.3%; p = 0.001). There were more patients with a positive S. stercoralis serology among those who were infected with T. cruzi (42.1% vs 25%; p = 0.023). Epidemiological variables were not associated with a positive strongyloidiasis serology. T. cruzi infection was more frequent among those with strongyloidiasis (61.5% vs 42.3%; p = 0.023). In multivariate analysis, T. cruzi infection was associated with a two-fold increase in the odds of strongyloidiasis (OR 2.23; 95% CI 1.07-4.64; p = 0.030). T. cruzi infection was associated with strongyloidiasis in LA migrants attending a tropical diseases unit even after adjusting for epidemiological variables. These findings should encourage physicians in non-endemic settings to implement a systematic screening for both infections in LA individuals.