Correction: Microtubule Destabilization Is Shared by Genetic and Idiopathic Parkinson’s Disease Patient Fibroblasts

Dr. Esteves and colleagues used a Parkinson's disease-derived cellular model, as cytoplasmic hybrid (cybrid) cell lines are, in which the mitochondrial DNA obtained by platelets of patients affected by idiopathic Parkinson's disease was transferred to human neuron-committed teratocarcinoma...

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Bibliographic Details
Published in:PloS one 2012-08, Vol.7 (8)
Main Authors: Cartelli, Daniele, Goldwurm, Stefano, Casagrande, Francesca, Pezzoli, Gianni, Cappelletti, Graziella
Format: Article
Language:English
Subjects:
Destabilization
Fibroblasts
Mitochondrial DNA
Parkinson's disease
Parkinsons disease
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Online Access:Get full text
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Summary:Dr. Esteves and colleagues used a Parkinson's disease-derived cellular model, as cytoplasmic hybrid (cybrid) cell lines are, in which the mitochondrial DNA obtained by platelets of patients affected by idiopathic Parkinson's disease was transferred to human neuron-committed teratocarcinoma cells, previously depleted of endogenous mitochondrial DNA. Dr. Esteves and colleagues suggested that the alteration of microtubule integrity is dependent on mitochondrial dysfunction, whereas our previous data proposed that microtubule destabilization leads to mitochondria damage (reference 15 in the article).
ISSN:1932-6203
1932-6203
DOI:10.1371/annotation/6db7193b-913a-42f2-aa7c-139d6e15142a