Serum thyroid-stimulating hormone and anti-thyroglobulin antibody are independently associated with lesions in spinal cord in central nervous system demyelinating diseases

Transverse myelitis (TM) is associated with neuromyelitis optica (NMO) and multiple sclerosis (MS). Early recognition of useful parameters may be helpful to distinguish their difference. This retrospective study analyzed thyroid parameters from 243 serum samples (relapse = 128; remission = 115) of 1...

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Bibliographic Details
Published in:PloS one 2014-08, Vol.9 (8), p.e100672-e100672
Main Authors: Long, Youming, Zheng, Yangbo, Chen, Mengyu, Zhang, Bin, Gao, Cong, Shan, Fulan, Yang, Ning, Fan, Yongxiang
Format: Article
Language:English
Subjects:
Abnormalities
Adolescent
Adult
Age
Aged
Antibodies
Aquaporin 4
Aquaporins
Autoantibodies - blood
Biology and Life Sciences
Central nervous system
Child
Cohort Studies
Demyelinating diseases
Demyelinating Diseases - blood
Demyelinating Diseases - epidemiology
Demyelinating Diseases - pathology
Demyelination
Education
Female
Hospitals
Humans
Immunoglobulins
Inflammatory diseases
Intravenous administration
Laboratories
Lesions
Male
Males
Medicine and Health Sciences
Methylprednisolone
Middle Aged
Multiple sclerosis
Multiple Sclerosis - blood
Multiple Sclerosis - epidemiology
Myelitis
Myelitis, Transverse - blood
Myelitis, Transverse - epidemiology
Nervous system
Neurology
Neuromyelitis
Neuromyelitis Optica - blood
Neuromyelitis Optica - epidemiology
Neurosciences
Parameters
Patients
Peroxidase
Regression analysis
Remission
Research and Analysis Methods
Serum levels
Spinal cord
Spinal Cord - pathology
Spinal Cord Diseases - blood
Spinal Cord Diseases - epidemiology
Thyroglobulin
Thyroid
Thyroid diseases
Thyroid-stimulating hormone
Thyrotropin - blood
Young Adult
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Summary:Transverse myelitis (TM) is associated with neuromyelitis optica (NMO) and multiple sclerosis (MS). Early recognition of useful parameters may be helpful to distinguish their difference. This retrospective study analyzed thyroid parameters from 243 serum samples (relapse = 128; remission = 115) of 178 patients with demyelinating diseases (NMO, n = 25; TM, n = 48; MS, n = 105). The relationship between thyroid and clinical parameters was analyzed. Patients with NMO and TM had a higher frequency of abnormal thyroid-stimulating hormone (TSH), anti-thyroglobulin antibodies (TG-Ab), and antithyroid peroxidase antibody (TPO-Ab) than MS patients (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0100672