Developmental changes of TGF-β1 and Smads signaling pathway in intestinal adaption of weaned pigs

Weaning stress caused marked changes in intestinal structure and function. Transforming growth factor-β1 (TGF-β1) and canonical Smads signaling pathway are suspected to play an important regulatory role in post-weaning adaptation of the small intestine. In the present study, the intestinal morpholog...

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Bibliographic Details
Published in:PloS one 2014-08, Vol.9 (8), p.e104589-e104589
Main Authors: Xiao, Kan, Song, Ze-He, Jiao, Le-Fei, Ke, Ya-Lu, Hu, Cai-Hong
Format: Article
Language:English
Subjects:
Animals
Biology and Life Sciences
Developmental stages
Hogs
Intestines - anatomy & histology
Intestines - physiology
Kinases
Morphology
mRNA
Mucosa
Nutrition
Permeability
Proteins
Restoration
RNA, Messenger - genetics
Rodents
Signal Transduction
Signaling
Smad Proteins - genetics
Smad Proteins - metabolism
Smad2 protein
Smad4 protein
Smad7 protein
Small intestine
Structure-function relationships
Swine - physiology
Transforming growth factor
Transforming Growth Factor beta1 - analysis
Transforming Growth Factor beta1 - metabolism
Transforming growth factor-b1
Villus
Weaning
Zonula occludens-1 protein
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Summary:Weaning stress caused marked changes in intestinal structure and function. Transforming growth factor-β1 (TGF-β1) and canonical Smads signaling pathway are suspected to play an important regulatory role in post-weaning adaptation of the small intestine. In the present study, the intestinal morphology and permeability, developmental expressions of tight junction proteins and TGF-β1 in the intestine of piglets during the 2 weeks after weaning were assessed. The expressions of TGF-β receptor I/II (TβRI, TβRII), smad2/3, smad4 and smad7 were determined to investigate whether canonical smads signaling pathways were involved in early weaning adaption process. The results showed that a shorter villus and deeper crypt were observed on d 3 and d 7 postweaning and intestinal morphology recovered to preweaning values on d 14 postweaning. Early weaning increased (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0104589