Long-term delivery of brain-derived neurotrophic factor (BDNF) from nanoporous silica nanoparticles improves the survival of spiral ganglion neurons in vitro

Sensorineural hearing loss (SNHL) can be overcome by electrical stimulation of spiral ganglion neurons (SGNs) via a cochlear implant (CI). Restricted CI performance results from the spatial gap between the SGNs and the electrode, but the efficacy of CI is also limited by the degeneration of SGNs as...

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Bibliographic Details
Published in:PloS one 2018-03, Vol.13 (3), p.e0194778-e0194778
Main Authors: Schmidt, Nadeschda, Schulze, Jennifer, Warwas, Dawid P, Ehlert, Nina, Lenarz, Thomas, Warnecke, Athanasia, Behrens, Peter
Format: Article
Language:English
Subjects:
Amino groups
Biocompatibility
Biology and Life Sciences
Biomedical materials
Brain
Brain research
Brain-derived neurotrophic factor
Care and treatment
Cell culture
Cell survival
Cochlea
Cochlear implants
Degeneration
Dorsal root ganglia
Electric contacts
Electrical stimuli
Engineering and Technology
Fibroblasts
Funding
Growth factors
Hair
Health aspects
Hearing loss
In vivo methods and tests
Inner ear
Medical research
Medical silicones
Medical treatment
Medicine and Health Sciences
Nanocomposites
Nanomedicine
Nanoparticles
Neurodegeneration
Neurons
Neuroprotection
Neurotrophic factors
Otolaryngology
Physiological aspects
Polymers
Protective coatings
Proteins
Research and Analysis Methods
Schmidt, Jennifer
Silica
Silicon dioxide
Spiral ganglion
Surgery
Surgical implants
Survival
Transplants & implants
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Description
Summary:Sensorineural hearing loss (SNHL) can be overcome by electrical stimulation of spiral ganglion neurons (SGNs) via a cochlear implant (CI). Restricted CI performance results from the spatial gap between the SGNs and the electrode, but the efficacy of CI is also limited by the degeneration of SGNs as one consequence of SHNL. In the healthy cochlea, the survival of SGNs is assured by endogenous neurotrophic support. Several applications of exogenous neurotrophic supply have been shown to reduce SGN degeneration in vitro and in vivo. In the present study, nanoporous silica nanoparticles (NPSNPs), with an approximate diameter of
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0194778