Chronic noise-exposure exacerbates insulin resistance and promotes the manifestations of the type 2 diabetes in a high-fat diet mouse model

Epidemiological studies have revealed that noise exposure was associated with an increased risk of type 2 diabetes mellitus (T2DM). However, the exact nature of that association remains to be elucidated. The present study is designed to examine the effects of chronic noise exposure on the developmen...

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Bibliographic Details
Published in:PloS one 2018-03, Vol.13 (3), p.e0195411-e0195411
Main Authors: Liu, Lijie, Huang, Yi, Fang, Cong, Zhang, Hongyu, Yang, Jing, Xuan, Chuanying, Wang, Fanfan, Lu, Haiying, Cao, Shuangfeng, Wang, Yongfang, Li, Shengwei, Sha, Jun, Zha, Mingming, Guo, Min, Wang, Jian
Format: Article
Language:English
Subjects:
Abnormalities
Biology and Life Sciences
Carbohydrates
Care and treatment
Chronic illnesses
Complications and side effects
Development and progression
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diet
Diet therapy
Dyslipidemia
Engineering and Technology
Environmental aspects
Epidemiology
Exposure
Fatty acids
Feeds
Glucose tolerance
Health risks
High fat diet
Hyperglycemia
Insulin
Insulin resistance
Intolerance
Laboratory animals
Life sciences
Lipolysis
Medicine and Health Sciences
Metabolism
Methods
Mice
Neurosciences
Noise
Noise levels
Noise pollution
Occupational exposure
Occupational safety
Physical Sciences
Physiology
Proteins
Rodents
Type 2 diabetes
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Summary:Epidemiological studies have revealed that noise exposure was associated with an increased risk of type 2 diabetes mellitus (T2DM). However, the exact nature of that association remains to be elucidated. The present study is designed to examine the effects of chronic noise exposure on the development of T2DM in combination with a high-fat-diet (HFD) in mice. Here we show that chronic noise exposure at 85 dB SPL (4 h /day, below the safety limit for occupational noise exposure) exaggerated multiple metabolic abnormalities induced by HFD in C57BL/6J male mice, including worsened glucose intolerance, insulin resistance, fasting hyperglycemia and dyslipidemia. Furthermore, noise exposure exhibited a paradoxical impact on fat accumulation and circulating levels of free fatty acid, indicating a potential stimulating effect of noise on lipolysis. These results provide first in vivo supporting evidence for the causative role of noise exposure in diabetogenesis and pinpoint a noise-associated increase in blood free fatty acid levels as a possible mediator accelerating the effect of noise on the development of insulin resistance and T2DM.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0195411